Awardees' Articles

HFSP Program Grant holders Nick Melosh and Andreas Schaeffer and colleagues

Tuesday 1st September 2015

Electrical recordings of delivery of drugs inside cells is a cornerstone of modern biotechnology. However, how materials enter or penetrate the cell wall is still something of a mystery. We show a new technique that demonstrates the ability of different materials and surfaces to cause membrane rupture.

 

HFSP Long-Term Fellow Fernando García-Moreno and Program Grant holder Zoltán Molnár

Monday 31st August 2015

Understanding development and evolution of the neocortex has important implications. Differential timing of developmental events sculpts the brains of different species into distinct organs. The latest investigations on the development of the dorsal forebrain in chick and mouse embryos showed a major difference between vertebrate brains. A delay in the neurogenic properties of a subset of progenitors is specific to mammals and could be responsible for the evolutionary origin of the corpus callosum...

 

HFSP Young Investigator Grant holders Justin Seymour and Roman Stocker and colleagues

Tuesday 25th August 2015

Corals develop important beneficial, and sometimes detrimental, relationships with a range of microorganisms, including algae and diverse populations of bacteria and archaea, but little is currently known about the microbial behaviors involved in the establishment and maintenance of coral-microbe interactions. We applied a suite of approaches, including microfluidic experiments and genomic analysis, to investigate the extent to which natural communities of coral associated microbes use deliberate...

 

HFSP Program Grant holders René Marc Mège and Benoit Ladoux and colleagues

Monday 24th August 2015

Cadherins are the major component of adherens junctions, holding cells together by forming 'trans' interactions with cadherin molecules in the plasma membrane of adjacent cells. Crystal structures of cadherin indicate that the protein can also form ‘cis’ interactions with E-cadherin molecules in the same cell membrane, but whether these interactions help organize cadherin in vivo, and how this might affect the function of adherens junctions, remains unclear.

 

HFSP Career Development Award holder Jeroen Van Zon and colleagues

Tuesday 21st July 2015

It is an open question how, during embryonic development, spatial patterns of gene expression are induced with high precision. By counting single mRNA molecules during vulva induction in the nematode worm <em>Caenorhabditis elegans</em>, we established that the induced cells dynamically control the level of gene expression by increasing their sensitivity to the external inductive signal.

 

HFSP Young Investigator Grant holder Giovanni Pezzulo and colleagues

Monday 20th July 2015

Recent evidence challenges the traditional serial (decide-then-act) view of decision making, showing that decision and action processes can run in parallel. Here, we present a formal model in which decisions and actions are considered and optimized&nbsp;jointly, and apply it to various dynamical choice tasks. A prominent aspect of this model is an analysis of how action processes influence decision processes and not only vice-versa as often proposed.

 

HFSP Long-Term Fellow Simon Chen and HFSP Young Investigator Grant holder Takaki Komiyama

Tuesday 14th July 2015

Imagine when you are learning to play a long string of notes on a piano or to make a golf swing at a driving range, what is changing in your brain that allows you to learn those movements? The motor cortex in the brain has been shown to play an active role in the learning of new motor skills, and here&nbsp;we describe a specific type of inhibitory neuron in the motor cortex that is responsible for&nbsp;gating the changes required for the learning of new skilled movements.

 

HFSP Career Development Award holder Shay Ben-Aroya and colleagues

Friday 26th June 2015

Our study used the baker yeast Saccharomyces cerevisiae as a model system to reveal for the first time how the dysfunctional proteasome, which is associated with age-related pathologies and all the major chronic neurodegenerative disorders, is controlled by the protein quality control machinery.

 

HFSP Long-Term Fellow Stephan Preibisch and colleagues

Monday 22nd June 2015

The ability to track fast moving particles in 3D is limited in classic light microscopy as image stacks are acquired as a series of two-dimensional planes. Here, we reconstruct data from multifocal-microscopy that instantaneously captures entire 3D image stacks of live cells and show that &beta;-actin mRNAs freely access the entire nucleus.

 

HFSP Cross-Disciplinary Fellow Ruben Portugues and colleagues

Thursday 18th June 2015

Animals use sensory evidence to decide what to do and when to do it. In fact, when presented with certain stimuli, it may take up to several seconds for an animal to react, even though action potentials, which govern the flow of information in the brain, last only a few milliseconds. Why?