Awardees' Articles

HFSP Career Development Award holder Magdalini Polymenidou and colleagues

Thursday 9th August 2018

The RNA-binding protein FUS, which localizes to the nucleus of normal neurons, forms cytoplasmic aggregates in a subset of patients with early onset frontotemporal dementia (FTD-FUS), via an uncharacterized mechanism. This study investigates the role of hypertonic stress in the initiation of FUS pathology and describes a new molecular mechanism active in neurons, but not astrocytes, which may contribute to the neuronal dysfunction in FTD-FUS patients.

 

HFSP Long-Term Fellow Kenji Sugioka and colleagues

Tuesday 7th August 2018

During animal development, cell division orientations are arranged in diverse angles to shape tissue and organs, but the mechanism to orchestrate the division axis diversity remains unknown. In this study, Sugioka and Bowerman found that different combinations of contact-dependent cues specify multiple cell division axes by directing a flow of myosin at the cell surface.

 

HFSP Career Development Award holder Pablo Manavella and colleagues

Monday 6th August 2018

A nuclear inactive reserve pool of the micro RNA biogenesis factor HYL1, in a phosphorylated state, is specifically protected inside the nucleus from dark/shade-induced degradation. Upon light restoration, this reserve pool is quickly dephosphorylated to rapidly restore miRNA production and switch the developmental program to light dependent growth.

 

HFSP Career Development Award holder Maximilian Fürthauer and colleagues

Thursday 19th July 2018

The characterization of a unifying mechanism governing left-right asymmetry in different phyla has long remained elusive. We show that Myosin1D, a previously identified regulator of Drosophila left-right asymmetry, is essential for the formation and function of the zebrafish left-right organizer, identifying thereby an evolutionarily conserved regulator of animal laterality.

 

HFSP Long-Term Fellow Dragomir Milovanovic and colleagues

Tuesday 17th July 2018

Neuronal transmission relies on the sustained release of neurotransmitters from synaptic vesicles (SVs) upon depolarization of neurons. Nerve terminals contain hundreds of SVs that form tight clusters. Despite being held together, vesicles are highly mobile within these clusters, so that they can be randomly recruited to the surface of the cell to release their content upon activation of the neuron. How this compact, yet dynamic organization, is achieved remained elusive. Several studies in the...

 

HFSP Long-Term Fellow Rebecca Turk-MacLeod and colleagues

Monday 18th June 2018

We show a new method to sort objects in groups or using a set of registers, which are then resorted iteratively. The result is a lossless enrichment process that leads to a very high purity and can cope with errors and highly dynamic populations.

 

HFSP Career Development Award holder Tomomi Kiyomitsu and colleagues

Friday 15th June 2018

During mitosis, dynamic plus ends of astral microtubules must be captured and pulled by cortical force-generating machinery, which positions the spindle to define daughter cell fate during both symmetric and asymmetric cell division.

 

HFSP Long-Term Fellow Takashi Fukaya and colleagues

Thursday 7th June 2018

Transvection is a process where regulatory DNAs located on one homolog regulate the transcription unit on the other homolog in trans. Lim and Heist et al. visualized transvection in living Drosophila embryos for the first time since the discovery of this process by E.B. Lewis in the 1950s.

 

HFSP Long-Term Fellow Avihu Yona and colleagues

Thursday 31st May 2018

Changes in gene regulatory networks often underlie evolutionary innovation, but it is unclear how evolutionarily accessible new regulatory features are. Here Yona et. al. show that minimal mutations can rapidly turn non-specific sequences into de novo promoters in bacteria.

 

HFSP Career Development Award holder Ziv Shulman and colleagues

Monday 28th May 2018

In order to mount a protective immune response against invading harmful pathogens, various types of immune cells must interact with each other. These interactions often occur in specialized niches within lymphoid organs as well as in sites of inflammation and tumor microenvironments. To identify and define the functions of immune cells in a specific location within an organ, in situ niche photolabeling was combined with gene expression analysis of single cells (single cell RNA-seq). By using this...