HFSP Long-Term Fellow Hans-Henning Kunz and colleagues
Monday 20th October 2014
Photosynthesis converts light into chemical energy and is the prerequisite for life on earth. It is divided into the light reaction, which captures light energy and dark reaction, which fixes atmospheric CO2. The polysaccharide starch represents the primary end product of the photosynthesis and thus the main energy storage. In all photoautotrophic eukaryotes these reactions are localized in the chloroplast. During the night when photosynthesis is inactive, starch is degraded and exported as maltose...
HFSP Long-Term Fellows Daniel Schramek, Ataman Sendoel and Slobodan Beronja and colleagues
Monday 13th October 2014
Modern genomics is uncovering hundreds of mutations associated with cancer, but mining this data for novel therapies is predicated on weeding out “bystander” alterations and identifying “driver” mutations as well as components responsible for tumorigenesis and metastasis. In this study, we devised and employed a novel direct in vivo RNAi screening methodology to simultaneously test function of hundreds of putative cancer genes within a single mouse and found novel tumors suppressors with...
HFSP Long-Term Fellow Andrew Pruszynski and colleagues
Monday 6th October 2014
A fundamental feature of the first neurons in the touch-processing pathway is that they branch in the skin and have many transduction sites. This study shows that this branching constitutes a peripheral neural mechanism for extracting information about the geometric features of touched objects, a capacity previously thought to be a hallmark of sophisticated processing in the cerebral cortex.
HFSP Long-Term Fellow Aviv Mezer and colleagues
Friday 19th September 2014
Properties of human brain tissue change across the lifespan. Modeling of white matter age changes measured with quantitative MRI shows that maturation reaches a peak at around age 40, and then begins to unravel. By the end of life, our brain’s fat levels return to about where they were at age 7. The time-courses of different MRI markers demonstrate that multiple biological processes drive changes in white-matter tissue properties over the lifespan.
HFSP grant awardees Roman Stocker and Assaf Vardi
Monday 15th September 2014
Do corals rely entirely on ocean currents to deliver nutrients for their survival? HFSP grantees Roman Stocker and Assaf Vardi set out to answer this question and made the stunning discovery showing that corals actually engineer their environment so as to improve the flow of water in the immediate vicinity.
HFSP Long-Term Fellow Nadine Gogolla and colleagues
Friday 1st August 2014
Many people with autism display atypical sensory processing, and in independent studies, abnormalities in a deep brain structure known as the insula. A new study from researchers at Harvard University reveals that across four different mouse models of autism, the development of sound-touch integration—important for social play in rodents—is impaired.This impairment reflects deficits in inhibitory circuit maturation in the insula and can be rescued by boosting inhibitory neurotransmission early...
HFSP Long-Term Fellow Ruben Portugues and colleagues
Wednesday 30th July 2014
Together with his colleagues, HFSP fellow Ruben Portugues studied the supra-spinal control of locomotion of Zebrafish larvae by attributing an important role to 4 identifiable cells in independently controlling two very specific behavioral parameters: bout duration and tail-beat frequency.
HFSP Long-Term Fellow Emmanuel Levy and colleagues
Thursday 17th July 2014
The way proteins are organized inside a living cell remains largely unknown. Levy and colleagues present a new way to probe this organization and measure the extent to which cytoplasmic and membrane proteins encounter each other.
HFSP Long-Term Fellow Volker Busskamp and colleagues
Friday 11th July 2014
The maintenance of the light sensitive “antennas” of photoreceptors in the retina is important for their function. We identified microRNAs as key players in this mechanism. With this knowledge, we have been able to induce the formation of light sensitive photoreceptors in cultured retinas derived from stem cells. This opens exciting new avenues for the study of blindness and its treatment.
HFSP Long-Term Fellow Sergi Regot and colleagues
Friday 20th June 2014
Single cells are intrinsically noisy and need to be analyzed individually. We describe a novel generalizable method to measure multiple kinase activities simultaneously in live single cells. Our technology opens the exciting possibility of dynamically analyzing multiple signaling networks, as well as cell cycle and a wide range of kinase mediated processes simultaneously at the single-cell level.