Awardees' Articles

HFSP Young Investigator Grant holders Monica Daley and Jonathan Hurst and colleagues

Thursday 30th October 2014

Ground-running birds have a striking ability to run over uneven terrain with agility and efficiency. In our HFSP supported work, we seek the fundamental task-level control priorities that underlie this suite of locomotion behaviors. We address this question with a novel combination of cross-species obstacle experiments and trajectory optimization modeling analysis. We deduce that birds from quail to ostrich, a 540-fold mass range, achieve such dynamic locomotion primarily by regulating leg safety...

 

HFSP Young Investigator Grant holder Rafael Carazo Salas and colleagues

Monday 27th October 2014

Classical genetics has typically focused on dissecting how genes or pathways control a given process within cells. However, many genes likely play roles in multiple processes, which are potentially linked to one another. Unravelling those multiple roles and links is a pressing challenge if we are to understand how healthy cells function normally as integrated systems and, conversely, how complex cellular pathologies arise in disease and how to fix them.

 

HFSP Long-Term Fellow Hans-Henning Kunz and colleagues

Monday 20th October 2014

Photosynthesis converts light into chemical energy and is the prerequisite for life on earth. It is divided into the light reaction, which captures light energy and dark reaction, which fixes atmospheric CO2. The polysaccharide starch represents the primary end product of the photosynthesis and thus the main energy storage. In all photoautotrophic eukaryotes these reactions are localized in the chloroplast. During the night when photosynthesis is inactive, starch is degraded and exported as maltose...

 

HFSP Long-Term Fellows Daniel Schramek, Ataman Sendoel and Slobodan Beronja and colleagues

Monday 13th October 2014

Modern genomics is uncovering hundreds of mutations associated with cancer, but mining this data for novel therapies is predicated on weeding out “bystander” alterations and identifying “driver” mutations as well as components responsible for tumorigenesis and metastasis. In this study, we devised and employed a novel direct in vivo RNAi screening methodology to simultaneously test function of hundreds of putative cancer genes within a single mouse and found novel tumors suppressors with...

 

HFSP Long-Term Fellow Andrew Pruszynski and colleagues

Monday 6th October 2014

A fundamental feature of the first neurons in the touch-processing pathway is that they branch in the skin and have many transduction sites. This study shows that this branching constitutes a peripheral neural mechanism for extracting information about the geometric features of touched objects, a capacity previously thought to be a hallmark of sophisticated processing in the cerebral cortex.

 

HFSP Long-Term Fellow Aviv Mezer and colleagues

Friday 19th September 2014

Properties of human brain tissue change across the lifespan. Modeling of white matter age changes measured with quantitative MRI shows that maturation reaches a peak at around age 40, and then begins to unravel. By the end of life, our brain’s fat levels return to about where they were at age 7. The time-courses of different MRI markers demonstrate that multiple biological processes drive changes in white-matter tissue properties over the lifespan.

 

HFSP grant awardees Roman Stocker and Assaf Vardi

Monday 15th September 2014

Do corals rely entirely on ocean currents to deliver nutrients for their survival? HFSP grantees Roman Stocker and Assaf Vardi set out to answer this question and made the stunning discovery showing that corals actually engineer their environment so as to improve the flow of water in the immediate vicinity.

 

HFSP Long-Term Fellow Nadine Gogolla and colleagues

Friday 1st August 2014

Many people with autism display atypical sensory processing, and in independent studies, abnormalities in a deep brain structure known as the insula. A new study from researchers at Harvard University reveals that across four different mouse models of autism, the development of sound-touch integration—important for social play in rodents—is impaired.This impairment reflects deficits in inhibitory circuit maturation in the insula and can be rescued by boosting inhibitory neurotransmission early...

 

HFSP Long-Term Fellow Ruben Portugues and colleagues

Wednesday 30th July 2014

Together with his colleagues, HFSP fellow Ruben Portugues studied the supra-spinal control of locomotion of Zebrafish larvae by attributing an important role to 4 identifiable cells in independently controlling two very specific behavioral parameters: bout duration and tail-beat frequency.

 

HFSP Long-Term Fellow Emmanuel Levy and colleagues

Thursday 17th July 2014

The way proteins are organized inside a living cell remains largely unknown. Levy and colleagues present a new way to probe this organization and measure the extent to which cytoplasmic and membrane proteins encounter each other.