HFSP Long-Term Fellow Pavan Ramdya and colleagues
Friday 21st April 2017
By optimizing the walking speed of a simulated insect, we discovered faster walking gaits for hexapod robots. These have never before been observed in nature. On the other hand, the fast tripod insect gait may be prevalent since it satisfies the need to climb up challenging terrain.
HFSP Cross-Disciplinary Fellow Shashi Thutupalli and colleagues
Tuesday 4th April 2017
Nematode worms engage in a primitive form of bacterial farming and public goods production as they forage and explore their environment. The resultant population dynamics and eco-evolutionary consequences are broadly applicable not only to worm-bacterial populations but can also be relevant in diverse situations such as epidemic spread, seed dispersal and the composition of the local ecologies which organisms inhabit.
HFSP Cross-Disciplinary Fellow Anupam Sengupta and HFSP Young Investigator Grant holder Roman Stocker and colleagues
Thursday 30th March 2017
It has long been recognized that turbulence is a primary determinant of plankton fitness and succession. However, it remains a riddle whether such species can actively respond, and rapidly adapt to a turbulent landscape. By bringing the 'ocean-in-the-lab' we found that phytoplankton can behaviourally respond to turbulent cues through a rapid change in shape, thus challenging a fundamental paradigm in oceanography that phytoplankton are passively at the mercy of turbulence.
HFSP Young Investigator Grant holders Keir C. Neuman and Mihály Kovács and colleagues
Friday 24th March 2017
DNA breaks can be repaired in an error-free manner by using the homologous region of an undamaged DNA template in a process called homologous recombination. However, imprecise selection of the homologous region can lead to cell death or cancer. This study revealed that novel patterns of RecQ helicase motion ensure precise recombination by specifically disrupting incorrect DNA pairing events.
HFSP Long-Term Fellow Karl Duderstadt and colleagues
Thursday 16th March 2017
The dynamic events that underlie chromosome duplication have long remained a mystery. Using a new multidimensional imaging approach, we discovered that the molecular assemblies responsible for copying DNA exploit a network of parallel enzymatic pathways to maintain robust coordination.
HFSP Long-Term Fellow Raunak Sinha and colleagues
Tuesday 14th March 2017
Our central vision is unable to detect rapidly changing visual inputs, such as flickering light, as well as our peripheral vision can. Where does this common perceptual difference originate in the visual system and what are the underlying neural mechanisms? We explored the cellular and circuit mechanisms in foveal and peripheral retina and unexpectedly uncovered that the perceptual difference in temporal sensitivity originates in the cone photoreceptors that transduce photons to electric signals...
HFSP Long-Term Fellow Kalyan Sinha and colleagues
Monday 13th March 2017
For a long time, it has not been possible to detect structural changes within the histone octamer core of a nucleosome due to limitations of the methods in use. In this study, using site-specific methyl-labeling and high-resolution NMR spectroscopy, we provide evidence of the existence of functionally important distortion of the octamer core in the presence of an ATP-dependent remodeling enzyme SNF2h.
HFSP Young Investigator Grant holders Tatiana Korotkova and Denis Burdakov and colleagues
Friday 10th March 2017
Food seeking is a complex behavior, crucial for survival. We identified a novel top-down pathway from medial prefrontal cortex to the lateral hypothalamus, which utilizes gamma synchronization to regulate food seeking by dynamic reorganization of functional cell groups in the hypothalamus.
HFSP Cross-Disciplinary Fellow Philip Bittihn and colleagues
Thursday 9th March 2017
Mutations in laboratory populations of simple organisms such as bacteria are of central interest in the context of experimental evolution and a major concern for bioengineers whose goal it is to equip them with evolutionarily stable added functionality. This study shows that the changes in population size as they are imposed by common experimental protocols can have a strong impact on the likeliness for mutations to spread through the population and makes quantitative predictions how the spectrum...
HFSP Long-Term Fellow Mariaceleste Aragona and colleagues
Tuesday 7th March 2017
One of the key questions in biology is to identify how tissues are repaired after trauma and understand how stem cells migrate, proliferate, and differentiate to repair tissue damage. We identified the cellular and molecular mechanisms that regulate wound healing in the skin.