HFSP Long-Term Fellow Manuel Irimia and colleagues
Thursday 1st October 2015
The recent finding that dozens of highly conserved tiny microexons exist in our genes and show striking neuronal-specific regulation suggests that microexons play crucial roles in brain development and function. However, these roles are largely unknown. By knocking out the major regulator responsible for the neuronal-specific regulation of microexons, nSR100/SRRM4, we obtained insights into the biological functions of microexons in mammalian brain development. Misregulation of microexons is associated...
HFSP Long-Term Fellow Roberto J. Brea and colleagues
Monday 28th September 2015
The tools of synthetic biology could allow the reconstitution of the necessary machinery to create synthetic membranes, as well as the intracellular constituents to generate specific functions, enabling the efficient construction of artificial cells. Herein, we describe relevant aspects of the design and preparation of minimal supramolecular architectures that can faithfully mimic or reconstruct the structure and/or function of living cells. Additionally, we report the spontaneous reconstitution...
HFSP Long-Term Fellow Matteo Fumagalli and colleagues
Friday 25th September 2015
The Inuit, the natives of Greenland, and their ancestors have been living in the extreme conditions of the Arctic for thousands of years and have been exposed to both cold annual temperatures and a traditional high-fat diet. We discovered that the Inuit genome has mutations in genes controlling how fat is metabolized, allowing them to physically adapt on a diet rich in omega-3 polyunsaturated fatty acids from marine mammals.
Press release for HFSP Career Development Award holder Rune Linding and colleagues
Thursday 24th September 2015
Cancer Genomics: Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.
HFSP Program Grant holders Daniel Forger, Hugh Piggins and Toru Takumi
Monday 14th September 2015
GABA is the only signal sent and received by all cells in the suprachiasmatic nucleus (SCN), the site of the central circadian pacemaker. We discovered separate and simultaneous mechanisms by which GABA in the SCN times fast electrical signals in cells, daily rhythms in the body and the time of year.
HFSP Young Investigator Grant holders Manuel Théry and Maxence Nachury and HFSP Program Grant holder Laurent Blanchoin and colleagues
Thursday 10th September 2015
A microfluidic device has been designed to attach and bend microtubules with hydrodynamic flows. Repeated sequences of microtubule bending revealed that microtubules soften under constraint but also that they could recover their stiffness by self-repairing.
HFSP Long-Term Fellow Romain Levayer and colleagues
Monday 7th September 2015
Cell competition is the mechanism that drives the elimination of slow proliferating cells (so called losers) by faster proliferating cells (winners) through apoptosis and can promote tumor expansion. By studying quantitatively cell competition through long term live imaging in Drosophila, we found that the probability of loser cell elimination correlates with the proportion of contact with winners and that winner cells actively mix with losers. The mixing increases the surface of contact between...
HFSP Program Grant holders Nick Melosh and Andreas Schaeffer and colleagues
Tuesday 1st September 2015
Electrical recordings of delivery of drugs inside cells is a cornerstone of modern biotechnology. However, how materials enter or penetrate the cell wall is still something of a mystery. We show a new technique that demonstrates the ability of different materials and surfaces to cause membrane rupture.
HFSP Long-Term Fellow Fernando García-Moreno and Program Grant holder Zoltán Molnár
Monday 31st August 2015
Understanding development and evolution of the neocortex has important implications. Differential timing of developmental events sculpts the brains of different species into distinct organs. The latest investigations on the development of the dorsal forebrain in chick and mouse embryos showed a major difference between vertebrate brains. A delay in the neurogenic properties of a subset of progenitors is specific to mammals and could be responsible for the evolutionary origin of the corpus callosum...
HFSP Young Investigator Grant holders Justin Seymour and Roman Stocker and colleagues
Tuesday 25th August 2015
Corals develop important beneficial, and sometimes detrimental, relationships with a range of microorganisms, including algae and diverse populations of bacteria and archaea, but little is currently known about the microbial behaviors involved in the establishment and maintenance of coral-microbe interactions. We applied a suite of approaches, including microfluidic experiments and genomic analysis, to investigate the extent to which natural communities of coral associated microbes use deliberate...