Awardees' Articles

HFSP Long-Term Fellow Yansong Miao and colleagues

Thursday 21st April 2016

Actin cables are crosslinked actin filament bundles that are nucleated by formin proteins in yeast. Actin cable regulates numerous biological processes for polarized cell growth, during which the cell cycle regulates the assembly and organization of actin filament. We report a phosphoregulation of actin crosslinking protein Sac6 by cyclin-dependent kinase 1 in budding yeast.

 

HFSP Program Grant holder Mathew Diamond and colleagues

Friday 15th April 2016

The brain is divided into functional circuits, each specialized for specific tasks: perception, memory, spatial navigation... How do these circuits work as a team when required? New research shows that when a rat is engaged in a tactile recognition task and needs to make a spatial choice based on previous knowledge, the animal's sensory, motor, and memory regions fall in step to a well-timed rhythmic choreography.

 

HFSP Career Development Award holder Michael Hothorn and colleagues

Tuesday 12th April 2016

Have you ever walked through a forest in the fall or through a meadow in late summer and wondered why trees and flowers shed their leaves? They are simply getting rid of organs that are no longer needed, preparing for the next step in their life cycle. But how does a leaf know when to let go? This process is regulated by the cell surface receptor HAESA, present in cells forming the tissue around the future break point. When it's time to shed an organ, a small peptide hormone called IDA instructs...

 

HFSP Young Investigator Grant holders Rosalind Allen, Thomas Bjarnsholt, Stephen Diggle and Vernita Gordon

Monday 11th April 2016

Biofilms are multicellular communities of interacting unicellular organisms that are embedded in a sticky and slimy polymer matrix. In the accepted paradigm of biofilm development, these communities initiate from single cells attached to a surface. However, we show that pre-formed, multicellular aggregates can play an important role in early biofilm development. This is because they have a growth advantage over single cells that arises from the interplay between the three-dimensional aggregate shape...

 

HFSP Long-Term Fellow Maximilian Joesch and colleagues

Thursday 7th April 2016

Neurons in the mouse's eye compare rod and cone signals to inform the brain about color. In humans, an analogous circuitry can explain color experiences in twilight.

 

HFSP Young Investigator Grant holders Calin Guet, Edo Kussell and Yuichi Wakamoto and colleagues

Monday 4th April 2016

Restriction-modification systems, a bacterial type of host defense mechanism, are imperfect in self/non-self discrimination, leading to autoimmunity in a small fraction of bacterial populations. Self-restriction is a stochastic process, whose fitness cost is environmentally dependent, and can explain previously observed depletion of restriction sites in a vast number of prokaryotic genomes.

 

HFSP Program Grant holders Cynthia Moss and Yossi Yovel and colleagues

Thursday 31st March 2016

It is currently unclear to what extent bats rely on vision and how they weigh and integrate visual and acoustic (sonar-based) information. In a recent joint project we studied how the Egyptian fruit bat (Rousettus aegyptiacus), an animal equipped with both high resolution vision and echolocation, adjusts sensory acquisition for the two senses.

 

HFSP Program Grant holder Cynthia Moss and colleagues

Tuesday 29th March 2016

Echolocating bats listen to echoes from their intense, high frequency vocalizations to build a 3D spatial representation of the environment.  When bats fly in groups and in cluttered environments, they must sort echoes from their own signals from those produced by neighboring bats, and we report on behavioral strategies in echolocation call adjustments and flight behaviors that enable them to operate in complex acoustic environments.

 

HFSP Program Grant holder Belinda Chang and colleagues

Thursday 24th March 2016

Reconstructed ancestral mammalian rhodopsins show altered function in the laboratory, indicative of adaptive evolution related to a nocturnal lifestyle. This is consistent with early theories and recent data suggesting nocturnality in ancient fossil lineages leading to mammals.

 

HFSP Long-Term Fellow Matilde Galli and colleagues

Wednesday 16th March 2016

The spindle assembly checkpoint delays mitotic progression when chromosomes are not properly attached to the mitotic spindle. Interestingly, checkpoint strengths vary between cells, and we show that during embryogenesis, cell size determines the strength of the spindle assembly checkpoint.