Awardees' Articles

HFSP Career Development Award holder Georg Keller and colleagues

Tuesday 17th January 2017

Movements are directly coupled to sensory feedback: moving the eyes, head, or body results in predictable visual feedback. What we show is that in mouse visual cortex there is a system of neurons, parallel to the classical visual system, that selectively responds to deviations from the expected visual feedback resulting from movements.

 

HFSP Program Grant holders Fan Bai and Teuta Pilizota and colleagues

Tuesday 10th January 2017

Bacteria live and grow under significant osmotic pressure - the difference between osmolarity inside the cell and that of the environment. When placed in environments with low osmolarity, bacteria manage to stay in control of their pressure and cell volume by opening a hole in the membrane and responding to competition arising from a propensity of the water and intracellular molecules to enter or exit the cell.</p>

 

HFSP Career Development Award holder Knut Drescher and colleagues

Thursday 5th January 2017

Bacteria in the environment often exist in communities, termed biofilms. In Escherichia coli biofilms, individual cells differ from one another with respect to many important physiological parameters. How this heterogeneity arises remains elusive, but an understanding of the extent to which it governs biofilm development is rapidly emerging.

 

HFSP Program Grant holders Benoit Ladoux, Chwee Teck Lim and René-Marc Mège and colleagues

Tuesday 3rd January 2017

Epithelial cells have a natural tendency to close gaps and this feature plays a crucial role in many biological processes such as embryological development, wound healing and apoptotic events. In the latter, the removal of cells in excess through extrusion is important to prevent accumulation of cells and tumor formation. The process can be triggered by multiple pathways that include apoptotic signaling, oncogenic transformation, and overcrowding of cells. Such events strongly depend on intercellular...

 

HFSP Long-Term Fellow Arnold Hayer and colleagues

Monday 19th December 2016

During collective cell migration, multiple cells migrate together as groups. Hayer et al. found that cadherin fingers, asymmetric junctional structures between cells, serve as structural guidance cues that allow neighboring collectively migrating endothelial cells to coordinate their movements with each other.

 

HFSP Career Development Award holder Roy Mukamel and colleagues

Friday 16th December 2016

Common wisdom states that 'practice makes perfect'. While indeed physical practice is most efficient, we developed a novel training scheme (and describe its neural correlates) that yields significant performance gains in a motor skill in the absence of voluntary movement.

 

HFSP Program Grant holders Uwe Bergmann, Philippe Wernet, Junko Yano and Athina Zouni and colleagues

Monday 12th December 2016

One of the most fundamental processes on earth --the photosynthetic splitting of water to generate the oxygen in the air that we all breathe-- is still not fully understood. New X-ray methods have now captured the first detailed images of the machinery that enables this process at room temperature.

 

HFSP Program Grant holder Boris Zemelman and colleagues

Thursday 8th December 2016

An important question in brain research is how neurons and the circuits they form process information to produce behavior. To understand what happens in a human brain, it is necessary to study a brain of similar complexity, such as that of a primate. Examining how the neurons in a brain region called the visual cortex process information about what we see is especially informative. This is because animals can be taught to perform different visual tasks, and because the visual cortex is relatively...

 

HFSP Young Investigator Grant holder Richard Benton and colleagues

Tuesday 6th December 2016

Pseudogenes are widely considered to be non-functional parts of the genome. New work has uncovered the phenomenon of pseudo-pseudogenes in the olfactory receptor repertoires of drosophilids that encode for functional receptor proteins through neuron-specific read-through of premature termination codons.

 

HFSP Young Investigator Grant holder Giuliano Scarcelli and colleagues

Monday 5th December 2016

Mechanical properties, such as stiffness, promise to provide new biomarkers and diagnostic indicators for underlying disease of biological organisms, from cells to organs. However, existing technology is invasive and/or too slow to provide mechanical information of large samples at high resolution. A new optical configuration that speeds up the acquisition by ~100 times is described below.