HFSP Long-Term Fellow Kun Li and colleagues
Friday 21st October 2016
In humans, gender specific differences in the prevalence of emotional disorders have been observed. A new study reveals the circuit and molecular mechanism that is responsible for gender biases in the occurrence of social and anxiety related disorders.
HFSP Program Grant holder Cristina Lo Celso and colleagues
Thursday 20th October 2016
New research is shedding light on how leukaemia cells can survive cancer treatment, suggesting new possibilities for stopping them in their tracks. Intravital microscopy reveals that leukaemia cells are highly motile and do not associate with specific cellular structures of the bone marrow.
HFSP Long-Term Fellow Jérémie Barral and colleagues
Monday 17th October 2016
A salient feature of neuronal networks is the maintenance of balance between excitatory and inhibitory drives (E-I balance). Maintaining a balance of E and I inputs to neurons is crucial and severe imbalances can lead to excessive or insufficient activity that will degrade coding or produce neuropathologies such as epileptic seizures, autism spectrum and schizophrenic disorders. Over the past decade, several key theories have been developed that specify the conditions under which E-I balance may...
HFSP Cross-Disciplinary Fellow David Maresca and colleagues
Monday 10th October 2016
Ultrasound is among the most widely used biomedical imaging modalities, revealing babies' first pictures and helping diagnose disease. Yet ultrasound has limited ability to image specific molecular targets due to the lack of nanoscale contrast agents.
HFSP Cross-Disciplinary Fellow Yong Wang and colleagues
Tuesday 27th September 2016
A novel arrangement of bacterial plasmids was observed using advanced fluorescence microscopy, shedding light on how bacteria maintain plasmids of multi-copies and the associated antibiotic resistant genes.
HFSP Long-Term Fellow Maximilian Joesch and colleagues
Monday 26th September 2016
Neurons connect with each other to form complex circuits that underlie mental activities. Mapping these connections to obtain a so-called wiring diagram is an essential step in learning how the brain works. At present, the only way to do this precisely enough is by using electron microscopy. However, this technique is so time-consuming that thousands of hours of work are typically required to image and analyze even the smallest tissue samples. To overcome this limitation, we developed a pipeline...
HFSP Long-Term Fellow Nicolas Lehrbach and colleagues
Tuesday 20th September 2016
A genetic screen in C. elegans illuminates the cellular response to proteasome dysfunction.
HFSP Program Grant holder Mark Bathe and colleagues
Monday 19th September 2016
Targeted cellular delivery of therapeutic messenger RNAs and CRISPR/Cas9 offer transformative potential for personalized medicine, as well as basic scientific investigation. To enable the non-viral packaging and delivery of these molecular payloads to target cellular destinations we have invented a versatile synthetic approach based on designer DNA nanoparticles.
HFSP Career Development Award holder Brice Bathellier and colleagues
Friday 16th September 2016
In humans, sounds that increase in intensity over time (up-ramp) are perceived as louder than down-ramping sounds. Here, we show that in mice this bias exists as well and is reflected in the complex nonlinearities of auditory cortex activity.
HFSP Career Development Award holder Caren Norden and colleagues
Thursday 15th September 2016
Light sheet fluorescence microscopy recently became a popular technique in developmental biology. This method allows for long-term imaging of many different samples with fast acquisition and most importantly, very low phototoxicity. However, so far most systems were custom-made and not available to the majority of biologists. This recently changed, when commercial systems entered the market. Here, we present a protocol explaining how to best make use of such systems and how to deal with the big...