HFSP Long-Term Fellow Volker Busskamp and colleagues
Friday 11th July 2014
The maintenance of the light sensitive “antennas” of photoreceptors in the retina is important for their function. We identified microRNAs as key players in this mechanism. With this knowledge, we have been able to induce the formation of light sensitive photoreceptors in cultured retinas derived from stem cells. This opens exciting new avenues for the study of blindness and its treatment.
HFSP Long-Term Fellow Sergi Regot and colleagues
Friday 20th June 2014
Single cells are intrinsically noisy and need to be analyzed individually. We describe a novel generalizable method to measure multiple kinase activities simultaneously in live single cells. Our technology opens the exciting possibility of dynamically analyzing multiple signaling networks, as well as cell cycle and a wide range of kinase mediated processes simultaneously at the single-cell level.
HFSP Long-Term Fellow Hans-Henning Kunz and colleagues
Thursday 22nd May 2014
Photosynthesis is the key biochemical reaction in plants but the molecular mechanisms of K+ transport across chloroplast membranes and their relevance for chloroplast function and photosynthesis remained unknown. We have identified and characterized three K+/ H+ transporters in chloroplast membranes and demonstrate their vital role for chloroplast osmoregulation and thylakoid density and photosynthesis. Surprisingly, high Na+ restored the photosynthetic activity in the mutant plants.
HFSP Long-Term Fellow Stephan Preibisch and HFSP Young Investigator Grant holder Pavel Tomancak and colleagues
Monday 19th May 2014
Modern light-sheet fluorescence microscopy is capable of imaging the development of an entire specimen at cellular level with high temporal resolution and provides unique opportunities for the observation of the same specimen from multiple angles (views). Deconvolution, a computational post-processing technique, can significantly increase spatial resolution of such datasets, but processing times are prohibitively long for large acquisitions. We developed a new multi-view deconvolution algorithm...
HFSP Young Investigator Grant holders Marco Cosentino Lagomarsino, Pietro Cicuta, and Bianca Sclavi and colleagues
Thursday 15th May 2014
Biophysical tools are increasingly providing key insights into understanding genome organisation in bacterial cells. We demonstrated the use of two complementary techniques, using manipulation by optical tweezers and high-throughput resistive pulse based sensing in micro-capillaries, to size individual bacterial genomes in a label-free manner.
HFSP Long-Term Fellow Ulises Rosas and colleagues
Tuesday 13th May 2014
How do plants know when to start flowering? What are the mechanisms underlying flowering diversity? We identified a natural polymorphism in CONSTANS, a regulatory gene controlling the flowering time developmental transition in Arabidopsis. We found that the polymorphism in CONSTANS controls transcriptional variation and flowering time diversity in Arabidopsis thaliana populations. This is one of the few natural regulatory polymorphisms known in Arabidopsis and other plants to be widely spread in...
HFSP Long-Term Fellow Fumi Kubo and colleagues
Friday 9th May 2014
During locomotion, the visual system is challenged by continuous movement of the visual scene that sweeps over the retina. How do animals sense and correct for visual motion during locomotion? We have identified various types of neurons that respond to visual motions, some of which might act as candidate circuit components to drive different compensatory behaviors.
HFSP Long-Term Fellow Conor McMeniman and colleagues
Thursday 8th May 2014
Have you ever been bothered by a mosquito? Lab generated mutant yellow fever mosquitoes were used to show that these insects are driven to find and bite humans by detecting combinations of carbon dioxide (CO2), heat, and odor that emanate from the human body.
HFSP Program Grant holders Philip Bevilacqua and Sarah Assmann and colleagues
Monday 28th April 2014
We developed a new approach to map the structure of RNA across the entire genome of any living organism. Our application of this method to the model plant Arabidopsis thaliana revealed novel insights into RNA splicing, alternative polyadenylation, translation, and RNA structure-function relationships.
HFSP Long-Term Fellow Michael Krieg and colleagues
Friday 25th April 2014
Forces are a ubiquitous challenge to all cells of our body and a protective mechanism has to be present. Some of the cells in our body have specifically evolved to detect these forces and convert mechanical energy into electrical signals that elicit an appropriate behavior. How they are able to withstand such mechanical insult without physical damage, while remaining sensitive enough to the stimulus to sense it, is not fully understood. Using the touch receptor neurons (TRNs) of C elegans as a model...