Awardees' Articles

HFSP Young Investigator Grant holders Malte Gather, Kristian Franze and Giuliano Scarcelli

Monday 24th July 2017

A new microscopy method, dubbed Elastic Resonator Interference Stress Microscopy (ERISM), images the extremely weak mechanical forces that living cells apply when they move, divide, and probe their environment. Forces exerted by cells are fundamental for many physiological processes including locomotion - such as during immune response or tumor metastasis - cell growth, wound healing, and tissue formation and repair. However, existing methods for monitoring cellular forces are often indirect and...

 

HFSP Cross-Disciplinary Fellow Simone Koehler and colleagues

Tuesday 18th July 2017

Meiosis is a specialized cell division process that separates each pair of homologous chromosomes to generate haploid reproductive cells such as sperm, eggs, and pollen. Using state-of-the-art super-resolution microscopy methods, we determined the three-dimensional architecture of the central core of meiotic chromosomes, known as 'axes', to better understand their functions in meiosis.

 

HFSP Career Development Award holder Geert van den Bogaart and colleagues

Tuesday 4th July 2017

Organellar trafficking is catalyzed by complex formation of SNARE proteins. In this study, a new technique based on fluorescence lifetime imaging microscopy is developed to visualize the subcellular location of SNARE complex formation.

 

HFSP Career Development Award holder Tatyana Chtanova and colleagues

Wednesday 28th June 2017

In cancer, immune cells infiltrate tumors but whether they can exit the tumor or where they go next was unknown until now. We have shown that activated T cells are the main immune cells to leave tumors and can move to other tumors and draining lymph nodes suggesting a potential role in patrolling for tumor metastases.

 

HFSP Long-Term Fellow Justin Kenney and colleagues

Friday 23rd June 2017

Human and animal behavior is thought to arise from many brain regions interacting with one another, forming a network. Combined computational and experimental approaches revealed that such functional brain networks can be used to predict brain region importance for particular behaviors.

 

HFSP Career Development Award holder Nadine Vastenhouw and colleagues

Thursday 22nd June 2017

How does an embryo know when it's time to activate its DNA? It turns out it's all about competition.

 

HFSP Career Development Award holder Ofer Yizhar and colleagues

Tuesday 20th June 2017

Pervasive fear memories, such as those associated with post-trauma and anxiety disorders, are thought to result from malfunctioning brain circuits. New research identifies an optogenetic intervention in mice that, when targeted to a major emotion-processing brain pathway, can lead to destabilization of fear memories, facilitating their extinction.

 

HFSP Long-Term Fellow Kayo Nozawa and colleagues

Monday 19th June 2017

Mediator is a multi-subunit co-activator of eukaryotic transcription that directly connects activator which is bound to regulatory DNA elements with RNA polymerase II. Here, we report on the crystal structure of the 15-subunit core Mediator (cMed) at 3.4 Å resolution. These results provide a framework for understanding Mediator function in the transcription pre-initiation complex (PIC).

 

HFSP Long-Term Fellow Dhiraj Bhatia and HFSP Program Grant holders Ludger Johannes and Yamuna Krishnan and colleagues

Friday 9th June 2017

Following molecules and organelles inside the cells over long durations has proved challenging, and has limited the pace of breakthroughs in cell biology. To this end, Bhatia et al. designed DNA-based nanocapsules that house fluorescent quantum dots simultaneously displaying a single endocytic ligand. These custom reagents allow one to track endocytic uptake and long-term organelle dynamics on live cells.

 

HFSP Program Grant holders Michael Brenner and Anne Pringle and colleagues

Thursday 8th June 2017

What allows the network-forming slime mold Physarum polycephalum to find the shortest path through a maze - despite lacking a nervous system? The key is a simple feedback: the slime mold sends information in the form of signaling molecules throughout its network of veins. Signaling molecules are transported by flowing fluids and cause fluid flow to increase. This positive feedback loop, on the one hand, speeds up information transfer, but at the same time fosters the growth of veins, precisely those...