Awardees' Articles

HFSP Program Grant holders Keith Shearwin and David Dunlap and colleagues

Monday 24th November 2014

Enhancers activate genes at long distance irrespective of position and orientation, so why don’t enhancers activate the wrong genes? The loop domain model proposes that DNA looping by insulators can restrict the reach of enhancers by generating isolated topological ‘DNA loop domains’. However, a biophysical understanding of this model has been lacking. By using well-characterised DNA looping proteins (Lac and Lambda CI repressors) in E. coli, we show that different loop arrangements can result...

 

HFSP Program Grant holders Karen Avraham, Ping Chen, Fumio Matsuzaki and David Sprinzak and colleagues

Thursday 20th November 2014

Planar cell polarity is a fundamental process during development, coordinating the alignment of neighboring cells within the plane of a tissue. A Human Frontier Science Program grant team from the USA, Israel and Japan, along with collaborators from Fudan University in China, has demonstrated a conserved role for Ankrd6 in regulating planar cell polarity in both the fruit fly and mouse.

 

HFSP Long-Term Fellow Volker Busskamp and colleagues

Monday 17th November 2014

Stem cell-derived neurons serve as attractive human neuronal model systems in health and disease. In order to understand in vitro neurogenesis, transcriptional changes over the time course of differentiation were analyzed and a network of key transcription factors that promoted the loss of pluripotency and rapid neurogenesis via progenitor states was revealed.

 

HFSP Long-Term Fellow Taran Gujral and colleagues

Thursday 13th November 2014

Metastasis is responsible for ~90% of cancer-associated mortality, yet progress has been slow in developing drugs that either specifically target metastasis or target cells with metastatic potential. Our study describes a new non-canonical Wnt pathway through Frizzled2 (Fzd2) that drives epithelial-mesenchymal transition (EMT) and tumor metastasis.

 

HFSP Program Grant holders Olivier Pertz, Gaudenz Danuser, Noo Li Jeon and colleagues

Friday 7th November 2014

Directed cell migration has special importance in processes such as cancer metastasis, immune surveillance and development. In these different processes, cell migration enables cancer cells to reach blood vessels for metastasis, immune cells to move to a site of infection, or the production of morphogenetic events that pattern our body. Understanding this process is therefore crucial to target these different processes in different path-physiological conditions. During cell motility, cells dynamically...

 

HFSP Long-Term Fellow Frank Jacobs and colleagues

Monday 3rd November 2014

An ongoing battle between KRAB zinc finger genes to control the invasion of mobile DNA elements has driven the evolution of greater complexity of primate genomes.

 

HFSP Long-Term Fellow Hugues Nury and colleagues

Sunday 2nd November 2014

Communication between neurons involves surface receptors, which can transform a chemical signal from the outside into a flux of ions across the cell membrane, i.e. an electrical signal. The new 3D structure of one of these receptors, the serotonin type 3 receptor, reveals its anatomy in detail and provides a snapshot of the full ion pathway.

 

HFSP Young Investigator Grant holders Monica Daley and Jonathan Hurst and colleagues

Saturday 1st November 2014

Ground-running birds have a striking ability to run over uneven terrain with agility and efficiency. In our HFSP supported work, we seek the fundamental task-level control priorities that underlie this suite of locomotion behaviors. We address this question with a novel combination of cross-species obstacle experiments and trajectory optimization modeling analysis. We deduce that birds from quail to ostrich, a 540-fold mass range, achieve such dynamic locomotion primarily by regulating leg safety...

 

HFSP Long-Term Fellow Janne Lempe and colleagues

Friday 31st October 2014

This study establishes nucleotide-resolution regulatory DNA landscapes and their dynamics in response to environmental cues such as light and heat, key to shaping plant growth and development, by mapping DNase I hypersensitive site (DHSs) combined with genomic footprinting.

 

HFSP Young Investigator Grant holder Rafael Carazo Salas and colleagues

Monday 27th October 2014

Classical genetics has typically focused on dissecting how genes or pathways control a given process within cells. However, many genes likely play roles in multiple processes, which are potentially linked to one another. Unravelling those multiple roles and links is a pressing challenge if we are to understand how healthy cells function normally as integrated systems and, conversely, how complex cellular pathologies arise in disease and how to fix them.