Awardees' Articles

HFSP Long-Term Fellow Rebecca Turk-MacLeod and colleagues

Monday 18th June 2018

We show a new method to sort objects in groups or using a set of registers, which are then resorted iteratively. The result is a lossless enrichment process that leads to a very high purity and can cope with errors and highly dynamic populations.

 

HFSP Career Development Award holder Tomomi Kiyomitsu and colleagues

Friday 15th June 2018

During mitosis, dynamic plus ends of astral microtubules must be captured and pulled by cortical force-generating machinery, which positions the spindle to define daughter cell fate during both symmetric and asymmetric cell division.

 

HFSP Long-Term Fellow Takashi Fukaya and colleagues

Thursday 7th June 2018

Transvection is a process where regulatory DNAs located on one homolog regulate the transcription unit on the other homolog in trans. Lim and Heist et al. visualized transvection in living Drosophila embryos for the first time since the discovery of this process by E.B. Lewis in the 1950s.

 

HFSP Long-Term Fellow Avihu Yona and colleagues

Thursday 31st May 2018

Changes in gene regulatory networks often underlie evolutionary innovation, but it is unclear how evolutionarily accessible new regulatory features are. Here Yona et. al. show that minimal mutations can rapidly turn non-specific sequences into de novo promoters in bacteria.

 

HFSP Career Development Award holder Ziv Shulman and colleagues

Monday 28th May 2018

In order to mount a protective immune response against invading harmful pathogens, various types of immune cells must interact with each other. These interactions often occur in specialized niches within lymphoid organs as well as in sites of inflammation and tumor microenvironments. To identify and define the functions of immune cells in a specific location within an organ, in situ niche photolabeling was combined with gene expression analysis of single cells (single cell RNA-seq). By using this...

 

HFSP Long-Term Fellow Katerina Guschanski and colleagues

Friday 25th May 2018

Wild animal populations decline rapidly as a result of human activities. However, it's the loss of peripheral populations, not simply reduction in population size, that has the most profound effect on gorilla genetic diversity.

 

HFSP Career Development Award holder Alex Sigal and colleagues

Thursday 24th May 2018

During infection, a virus needs to balance making enough copies of itself with ensuring that its host cell survives to allow the new virus copies to spread. Jackson et al. found that attenuating HIV by using partially effective therapy can increase the number of infected host cells by reducing host cell death.

 

HFSP Long-Term Fellow Johannes Kohl and colleagues

Friday 4th May 2018

How complex, multi-component behaviors are controlled by the brain has remained elusive. We have uncovered how a small population of genetically defined neurons in the mouse brain orchestrates discrete elements of parental behavior.

 

HFSP Career Development Award holder Jan Brugues and colleagues

Thursday 26th April 2018

The mitotic spindle is the protein machinery that segregates the genetic material to the two daughter cells during cell division. Its size is of crucial importance for proper functioning. Despite the fact that most of the building blocks of the spindle are known, we still do not understand how they self-organize to set the size of the structure. By combining experiments and theory we found that the upper size limit of the mitotic spindle is controlled by the creation of the main building blocks,...

 

HFSP Program Grant holders Olivier Hamant, Chun Biu Li, Adrienne Roeder and Richard Smith and colleagues

Friday 13th April 2018

Many plant epidermal cells form interlocking shapes that look like jigsaw puzzle pieces. However, scientists have struggled to understand how these complex shapes benefit the plant. We proposed that the puzzle cell shape allows the plant to create large cells in the epidermis, preventing them from bulging out excessively under the high stresses caused by turgor pressure. We tested our hypothesis with a computer simulation model of the emergence of these intricate forms, based on the feedback between...