Awardees' Articles

HFSP Career Development Award holder Suvendra Bhattacharyya and colleagues

Thursday 25th August 2016

In mammalian cells, gene expression is usually under tight regulation where tiny regulatory RNAs, known as microRNAs, play a major role in controlling expression of proteins. When the cells are under stress they undergo a robust change in gene expression to combat stress by putting on several genes that are otherwise repressed by microRNAs. HFSP CDA awardee Suvendra Bhattacharyya and colleagues have now identified a new mechanism of stress induced regulation of these tiny regulatory RNAs in mammalian...

 

HFSP Program Grant holders Michael Shadlen and Daniel Wolpert and colleagues

Monday 22nd August 2016

Decisions take time to form, can have different levels of accuracy and are associated with a subjective degree of confidence that our decision is correct. The same mechanism used to determine our initial decision and confidence explains why people may change their mind leading to vacillations in both confidence and decisions.

 

HFSP Cross-Disciplinary Fellow Andela Saric and colleagues

Thursday 28th July 2016

Certain protein structures, such as the pathological amyloid fibrils that are involved in several neurodegenerative disorders, manage to replicate without any additional assistance. The process of fibril self-replication is governed by a simple physical mechanism: the build-up of healthy proteins on the surface of existing fibrils.

 

HFSP Program Grant holder Alexei Kornyshev and colleagues

Tuesday 26th July 2016

Homologous recombination can accurately repair DNA double strand breaks that might otherwise be fatal. It can also combine parts of chromosomes from two parents into one single chromosome, allowing viable offspring to be genetically different from both parents.

 

HFSP Young Investigator Grant holders Friedrich Frischknecht and Jake Baum and colleagues

Saturday 23rd July 2016

Malaria parasites can move at incredible speed. Genetic and biophysical manipulation of the parasites showed how they organize actin filaments into higher order assemblies to achieve fast motility.

 

HFSP Long-Term Fellow Yamato Yoshida and colleagues

Tuesday 19th July 2016

Chloroplast division is carried out by a ring containing FtsZ1 and FtsZ2 proteins, which originated from a bacterial tubulin-like protein FtsZ. However, molecular mechanisms of the chloroplast FtsZ ring comprising two types of FtsZs remain unclear. This study demonstrates that FtsZ1 and FtsZ2 can heteropolymerize into a contractible ring in cells of the yeast Pichia pastoris. Our findings suggest that the evolutionary duplication of FtsZ in plants may have increased the mobility and kinetics of...

 

HFSP Long-Term Fellow Hansong Ma and colleagues

Monday 18th July 2016

In addition to favouring traits that enhance organismal fitness, evolution favours selfish gains in replication or transmission. By generating various Drosophila lines with two mitochondrial genotypes, we reveal the impact of selfish selection on how co-residing mitochondrial genomes compete for transmission.

 

HFSP Young Investigator Grant holders Maria Geffen and Judit Gervain and colleagues

Friday 8th July 2016

HFSP investigators Gervain and Geffen and colleagues discovered that the newborn human brain is specialized for processing natural sounds. This sensitivity may underlie our ability to perceive and comprehend speech.

 

HFSP Young Investigator Grant holders Jayachandran Gopalakrishnan and Haitao Li and colleagues

Thursday 30th June 2016

Centrioles are microtubule-based eukaryotic structures that build centrosomes and cilia, which are required for accurate cell division and cellular signaling. Centrioles have highly conserved architecture displaying defined numbers and lengths of microtubules. How this occurs has remained unknown and presents an outstanding challenge in biology. Using X-ray crystallography and biochemical and in vivo functional assays, the authors delineated how CPAP regulates delivery of its bound-tubulin to define...

 

HFSP Long-Term Fellow Samuel Wagner and colleagues

Thursday 16th June 2016

Macromolecular machines for delivery of bacterial effector proteins are a common means of interaction of pathogens with their eukaryotic host but these machines’ structure and function are often ill defined. We have determined the stoichiometry of the complete needle complex of a Salmonella type III secretion system using a combined quantitative proteomics approach to facilitate future functional investigations.