Awardees' Articles

HFSP Long-Term Fellow Maximilian Joesch and colleagues

Monday 26th September 2016

Neurons connect with each other to form complex circuits that underlie mental activities. Mapping these connections to obtain a so-called wiring diagram is an essential step in learning how the brain works. At present, the only way to do this precisely enough is by using electron microscopy. However, this technique is so time-consuming that thousands of hours of work are typically required to image and analyze even the smallest tissue samples. To overcome this limitation, we developed a pipeline...

 

HFSP Long-Term Fellow Nicolas Lehrbach and colleagues

Tuesday 20th September 2016

A genetic screen in C. elegans illuminates the cellular response to proteasome dysfunction.

 

HFSP Program Grant holder Mark Bathe and colleagues

Monday 19th September 2016

Targeted cellular delivery of therapeutic messenger RNAs and CRISPR/Cas9 offer transformative potential for personalized medicine, as well as basic scientific investigation. To enable the non-viral packaging and delivery of these molecular payloads to target cellular destinations we have invented a versatile synthetic approach based on designer DNA nanoparticles.

 

HFSP Career Development Award holder Brice Bathellier and colleagues

Friday 16th September 2016

In humans, sounds that increase in intensity over time (up-ramp) are perceived as louder than down-ramping sounds. Here, we show that in mice this bias exists as well and is reflected in the complex nonlinearities of auditory cortex activity.

 

HFSP Career Development Award holder Caren Norden and colleagues

Thursday 15th September 2016

Light sheet fluorescence microscopy recently became a popular technique in developmental biology. This method allows for long-term imaging of many different samples with fast acquisition and most importantly, very low phototoxicity. However, so far most systems were custom-made and not available to the majority of biologists. This recently changed, when commercial systems entered the market. Here, we present a protocol explaining how to best make use of such systems and how to deal with the big...

 

HFSP Young Investigator Grant holder Angela Hay and Program Grant holder Richard Smith and colleagues

Tuesday 13th September 2016

Exploding seed pods are a dramatic example of the many and varied strategies that plants use to disperse their seeds. The energy to power these explosions was thought to be generated through the seed pods deforming as they dried out. But in the case of popping cress (Cardamine hirsuta) this turns out not to be so. These seed pods don't wait to dry before they explode.

 

HFSP Program Grant holder Doug Altshuler and colleagues

Monday 12th September 2016

Birds are capable of rapid and precise feats in flight. A new study reveals how flying hummingbirds use the vertical size and position of features in their environment to make course adjustments in the air.

 

HFSP Long-Term Fellow Takashi Fukaya and colleagues

Thursday 8th September 2016

Recent quantitative imaging studies revealed that intermittent bursts of de novo transcription is a general property of gene regulation. However, the underlying mechanism of transcriptional bursting has remained unanswered. We employed newly developed real time monitoring of transcription activities in living Drosophila embryos and showed that enhancers control the frequency of transcriptional bursting to regulate the level of gene expression during development. We also showed that a shared enhancer...

 

HFSP Program Grant holders Arezki Boudaoud, Chun-Biu Li, Adrienne Roeder and Richard Smith and colleagues

Monday 29th August 2016

How do organs grow to reach the same size? Counterintuitively, randomness in cell growth is important to produce organs of uniform size and shape.

 

HFSP Career Development Award holder Suvendra Bhattacharyya and colleagues

Thursday 25th August 2016

In mammalian cells, gene expression is usually under tight regulation where tiny regulatory RNAs, known as microRNAs, play a major role in controlling expression of proteins. When the cells are under stress they undergo a robust change in gene expression to combat stress by putting on several genes that are otherwise repressed by microRNAs. HFSP CDA awardee Suvendra Bhattacharyya and colleagues have now identified a new mechanism of stress induced regulation of these tiny regulatory RNAs in mammalian...