Awardees' Articles

HFSP Career Development Award holder Knut Drescher and colleagues

Tuesday 19th February 2019

Most multicellular systems display collective self-organization on length scales that are much larger than individual cells. Establishing mechanistic, causal connections between intracellular processes, cellular behaviors, and multicellular organization is a major challenge in the life sciences. HFSP Career Development Awardee Knut Drescher and colleagues have now demonstrated a general approach for discovering basic mechanisms that organize bacterial swarm development over five orders of magnitude...

 

HFSP Long-Term Fellow Riccardo Beltramo and colleagues

Monday 18th February 2019

This study shows the discovery of a "second" visual system in the mouse cerebral cortex, whose activity is driven by an ancient visual sensory processing center.

 

HFSP Cross-Disciplinary Fellow Dan Bracha and colleagues

Friday 8th February 2019

Eukaryotic cells compartmentalize their contents into diverse specialized organelles, many of which can maintain their distinctive composition of mobile biomolecules even in the absence of a physical barrier such as a lipid membrane. In recent years, various membrane-free organelles were found to display liquid like properties, suggesting that they were the product of a liquid-liquid phase separation process, in which concentrated aqueous condensates of weakly interacting biomolecules coexist with...

 

HFSP Long-Term Fellow Katerina Guschanski and colleagues

Wednesday 6th February 2019

The recent dramatic population decline in the critically endangered Grauer's gorilla has left it with reduced genetic diversity, increased levels of inbreeding and more harmful mutations compared to 100 years ago.

 

HFSP Program Grant holders Joerg Enderlein, Dan Oron, Antoine Triller and Shimon Weiss and colleagues

Tuesday 5th February 2019

Kuo et al. describe semiconductor voltage nanosensors for optical recording of neuronal signals. These sensors operate via a unique nanoscale phenomena - the quantum confined Stark effect, whereby their emission color and intensity change upon the modulation of the neuron's membrane potential.

 

HFSP Young Investigator Grant holder Michael Halassa and colleagues

Friday 1st February 2019

In this study, the authors trained mice on a rule switching task for the first time. They found that, similar to primates (including humans), an area of the brain called the prefrontal cortex is involved, but that for it to function properly requires configuration signals from another structure called the mediodorsal thalamus.

 

HFSP Long-Term Fellow Kotaro Fujii and colleagues

Wednesday 30th January 2019

Eukaryote specific expansion segments (ESs) in the rRNA increase fidelity of mRNA translation. ESs are enigmatic insertions, the longest of which resemble tentacle-like extensions. We reveal that ES27L acts as RNA scaffold to recruit nascent protein processing enzymes to increase enzymatic activity and translation fidelity.

 

HFSP Long-Term Fellow Samuel Ojosnegros and colleagues

Tuesday 29th January 2019

Proteins continuously interact with other proteins in the cell, yet revealing these interactions in live-cell microscopy is technically challenging. Using statistical tools we designed the Enhanced Number and Brightness method, which quantifies and maps protein aggregation in live cells from high resolution movies.

 

HFSP Program Grant holders Ben Goult, Jie Yan and colleague, Martin Schwartz

Thursday 24th January 2019

It is becoming evident that cells interpret classical signaling pathways in the context of the mechanical forces experienced by the cell. The protein talin functions as a Mechanosensitive Signaling Hub (MSH), engaging different signaling molecules as a function of mechanical force to elicit different cellular behaviors (Goult et al., 2018).

 

HFSP Career Development Award holder Yuval Rinkevich and colleagues

Tuesday 15th January 2019

Adhesions are fibrous bands that glue organ surfaces with one another or with the walls of the cavity they reside in. It is the most common side-effect of abdominal surgery, inflammation, infections, or even in response to dialysis fluid. The ramifications of adhesions range from pelvic pain, obstruction of organ movement, female infertility, to severe organ failure.