Awardees' Articles

HFSP Program Grant holders Joseph Kirschvink, Ayumu Matani and Shinsuke Shimojo and colleagues

Friday 22nd March 2019

Although most humans are not consciously aware of the geomagnetic stimuli that they encounter in everyday life, we found two classes of ecologically-relevant rotations of Earth-strength magnetic fields that produce strong, specific and repeatable effects on human brainwave activity in the EEG alpha band (8-13 Hz); EEG discriminates in response to different geomagnetic field stimuli.

 

HFSP Long-Term Fellow Miguel Coelho and colleagues

Monday 11th March 2019

It was postulated that the favorite route towards cancer initiation involves two-hits, disrupting both copies of a genome guardian gene. This idea has prevailed over the last 60 years. Now, using experimental evolution, the authors demonstrated that a single-hit suffices to cause genetic instability, and discovered genes that mutate to trigger instability in yeast and human cells, which belong to non-canonical functional classes. This means that cells are more likely to become genetically unstable...

 

HFSP Cross-Disciplinary Fellow George Spyropoulos and colleagues

Friday 8th March 2019

We designed and developed novel transistor architecture and material to build better bioelectronic devices. For the first time, we were able to make a transistor that can communicate using ions, the body's charge carriers, at speeds fast enough to perform complex computations required for neurophysiology.

 

HFSP Program Grant holder Nadrian Seeman and colleagues

Monday 4th March 2019

Replication using large surfaced DNA tiles leads to exponential growth, with each seed producing a single daughter. Replication with cross-shaped tiles, using their edges, produces litters of offspring, through a crystalline intermediate. These intermediates have great potential for scattering studies.

 

HFSP Career Development Award holder Knut Drescher and colleagues

Tuesday 19th February 2019

Most multicellular systems display collective self-organization on length scales that are much larger than individual cells. Establishing mechanistic, causal connections between intracellular processes, cellular behaviors, and multicellular organization is a major challenge in the life sciences. HFSP Career Development Awardee Knut Drescher and colleagues have now demonstrated a general approach for discovering basic mechanisms that organize bacterial swarm development over five orders of magnitude...

 

HFSP Long-Term Fellow Riccardo Beltramo and colleagues

Monday 18th February 2019

This study shows the discovery of a "second" visual system in the mouse cerebral cortex, whose activity is driven by an ancient visual sensory processing center.

 

HFSP Cross-Disciplinary Fellow Dan Bracha and colleagues

Friday 8th February 2019

Eukaryotic cells compartmentalize their contents into diverse specialized organelles, many of which can maintain their distinctive composition of mobile biomolecules even in the absence of a physical barrier such as a lipid membrane. In recent years, various membrane-free organelles were found to display liquid like properties, suggesting that they were the product of a liquid-liquid phase separation process, in which concentrated aqueous condensates of weakly interacting biomolecules coexist with...

 

HFSP Long-Term Fellow Katerina Guschanski and colleagues

Wednesday 6th February 2019

The recent dramatic population decline in the critically endangered Grauer's gorilla has left it with reduced genetic diversity, increased levels of inbreeding and more harmful mutations compared to 100 years ago.

 

HFSP Program Grant holders Joerg Enderlein, Dan Oron, Antoine Triller and Shimon Weiss and colleagues

Tuesday 5th February 2019

Kuo et al. describe semiconductor voltage nanosensors for optical recording of neuronal signals. These sensors operate via a unique nanoscale phenomena - the quantum confined Stark effect, whereby their emission color and intensity change upon the modulation of the neuron's membrane potential.

 

HFSP Young Investigator Grant holder Michael Halassa and colleagues

Friday 1st February 2019

In this study, the authors trained mice on a rule switching task for the first time. They found that, similar to primates (including humans), an area of the brain called the prefrontal cortex is involved, but that for it to function properly requires configuration signals from another structure called the mediodorsal thalamus.