Awardees' Articles

HFSP Long-Term Fellow Ze'ev Melamed and colleagues

Monday 14th January 2019

Several neurodegenerative conditions including most instances of amyotrophic lateral sclerosis and frontotemporal dementia are characterized by mislocalization of the nuclear RNA binding protein TDP-43. Among widespread TDP-43-mediated RNA processing alterations, suppression of the neuronal stathmin-2 protein from premature polyadenylation of its mRNA is shown to be crucial for defects in axonal regeneration associated with TDP-43 loss of function, highlighting stathmin-2 as a novel therapeutic...

 

HFSP Young Investigator Grant holders Jay Gopalakrishnan and Haitao Li and colleagues

Friday 11th January 2019

In contrast to normal cells, cancer cells harbor extra centrosomes and centrosome amplification is a hallmark of cancer cells. We discovered a biochemically tunable mechanism to regulate centrosomes activity. Targeting this mechanism caused mitotic catastrophe and selective killing of cancer cells with extra centrosomes.

 

HFSP Long-Term Fellow Ariana Strandburg-Peshkin and colleagues

Thursday 10th January 2019

Turn-taking is a basic feature of human communication, but other animals also take turns. During group calling sessions, we find that meerkats avoid overlapping their group-mates by suppressing their calls when they hear others vocalizing.

 

HFSP Cross-Disciplinary Fellow Arnold Mathijssen and colleagues

Monday 10th December 2018

How do bacteria gather nutrients when they cluster in dense colonies? HFSP fellow Arnold Mathijssen discovered that many individual cells can cooperate to produce large vortex flows that supply new resources.

 

HFSP Long-Term Fellow Benyamin Rosental and colleagues

Friday 7th December 2018

Through functional and molecular characterization on the cellular level of a colonial chordate animal we have found the evolutionary origins of our own immune and the blood-forming systems.

 

HFSP Cross-Disciplinary Fellow Pietro Artoni and colleagues

Tuesday 4th December 2018

High-density Electroencephalography (EEG) and single-neuron calcium imaging are two complementary techniques for studying brain computation in vivo, enabling the electric waves on the brain surface and the neuronal code of the biological networks that originate the waves to be measured. By nanofabricating dense and transparent multi-electrode arrays, EEG and single-neuron calcium activity can be simultaneously measured in the mouse visual cortex, providing a new tool to better understand cortical...

 

HFSP Long-Term Fellow Raya Sorkin and colleagues

Thursday 15th November 2018

Mechanical properties of cells are important reporters of a cell's condition, as they often change upon disease. We have developed a new approach to measure mechanical properties of cells using acoustically exerted forces. This method allowed us to reveal that red blood cells become more deformable when they uptake extracellular vesicles.

 

HFSP Program Grant holder David Lambert and colleagues

Thursday 8th November 2018

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HFSP Career Development Award holder Patrick Mueller and colleagues

Tuesday 16th October 2018

During embryo development, two molecules adjust tissue proportions to the size of the embryo.

 

HFSP Career Development Award holder Andrea Pauli and colleagues

Monday 15th October 2018

Research in the Pauli lab has discovered a new protein that is essential for species-specific fertilization in fish. The story was recently published in Science.