Awardees' Articles

HFSP Young Investigator Grant holders Pance Naumov, Pascal Didier, Lukas Hintermann and Michel Sliwa and colleagues

Tuesday 14th February 2017

The different color of bioluminescent light emitted by different organisms has inspired several decades of inconclusive research efforts and debates on its mechanism and the underlying photochemistry. Now, mathematical analysis of the spectra of firefly oxyluciferin, the emitting molecule in fireflies embedded in the bioluminescent enzyme luciferase, has for the first time provided direct insight into the mechanistic complexity of this natural system for generation of cold light.


HFSP Long-Term Fellow Ulrich Braunschweig and colleagues

Monday 13th February 2017

Alternative splicing of gene transcripts gives rise to multiple products from a single gene, and plays important roles in cell differentiation. A new screening approach reveals that transcription factors regulate the process at multiple levels.


HFSP Long-Term Fellow Kenji Sugioka and colleagues

Thursday 9th February 2017

The centriole is a cylinder-shaped non-membrane organelle that has vital roles in cell division and sensing in animal cells. Similar to DNA replication, the centriole has to be duplicated before cell division to maintain its number. A new study by Sugioka et al. identified the earliest acting protein in the centriole duplication pathway.


HFSP Young Investigator Grant holders Colin Jackson, Harald Janovjak and Christian Henneberger and colleagues

Tuesday 7th February 2017

Optical biosensors can allow us to visualize the spatial, and temporal, distribution of various small molecules in plants, animals and microbes. However, the construction of effective sensors is not trivial. In this work we have used computational design to automate the selection of sites at which to attach fluorescent dyes to allow the straightforward conversion of solute binding proteins into biosensors.


HFSP Young Investigator Grant holder William Ryu and colleagues

Monday 6th February 2017

Although the nematode C. elegans has a simple nervous system, it has a complex response to changes in temperature. For small changes in temperature, such as the worm experiences when moving in a shallow thermal gradient, the worm can perform thermotaxis and migrate to a temperature that it prefers. However, if the temperature changes are very fast or very large, the worm will respond noxiously and attempt to escape the stimulus. The neurons and their signals that control these behaviors have not...


HFSP Long-Term Fellow Einat Segev and colleagues

Friday 3rd February 2017

Microscopic algae that live in the ocean release countless tons of oxygen into the atmosphere each year. Widespread algae - known as coccolithophores - surround their little plant-like body with a mineral shell made of a material similar to chalk. These microscopic algae form seasonal blooms. Over several weeks in early summer, the algae grow to enormous numbers and cover hundreds of thousands of square kilometers in the ocean. These blooms become so vast that satellites can detect them. However...


HFSP Program Grant holders Daniel Wolpert and Michael Shadlen and colleagues

Thursday 2nd February 2017

In tasks that require a number of decisions to achieve a goal, confidence in one decision affects the way the brain chooses to make the subsequent decision.


HFSP Long-Term Fellow William Durham and colleagues

Monday 30th January 2017

Most of what we know about microbial communities comes from studying cells in the laboratory as they grow in liquid culture. In these well-mixed conditions, evolution selects for the species that can reproduce the fastest. However, more than 95% of the bacteria on Earth live in complex porous environments like soil where they form surface attached biofilms.


HFSP Career Development Award holder Pedro Beltrao and colleagues

Friday 27th January 2017

Kinase-driven signalling is crucial for the coordinated adjustment of cellular changes and cell decision making. However, measuring the changes of activity for a large number of kinases remains a difficult challenge. Ochoa et al. inferred, from publicly available mass spectrometry data, the kinase regulation of 215 kinases under 399 different perturbations, allowing for a systematic study of the fundamental rules governing cellular signalling.


HFSP Young Investigator Grant holder Flavio Frohlich and colleagues

Thursday 26th January 2017

Anatomically and functionally connected brain regions form networks that collectively give rise to sensory, motor, and cognitive functions. Dr. Frohlich and his team revealed that the ferret brain exhibits such networks including the default mode network, which has been implicated in human psychiatric disorder.