Awardees' Articles

HFSP Career Development Award holder Pedro Beltrao and colleagues

Friday 27th January 2017

Kinase-driven signalling is crucial for the coordinated adjustment of cellular changes and cell decision making. However, measuring the changes of activity for a large number of kinases remains a difficult challenge. Ochoa et al. inferred, from publicly available mass spectrometry data, the kinase regulation of 215 kinases under 399 different perturbations, allowing for a systematic study of the fundamental rules governing cellular signalling.

 

HFSP Young Investigator Grant holder Flavio Frohlich and colleagues

Thursday 26th January 2017

Anatomically and functionally connected brain regions form networks that collectively give rise to sensory, motor, and cognitive functions. Dr. Frohlich and his team revealed that the ferret brain exhibits such networks including the default mode network, which has been implicated in human psychiatric disorder.

 

HFSP Cross-Disciplinary Fellow Fernando Montealegre-Z and colleagues

Tuesday 24th January 2017

An acute and advanced hearing system which allows bush-crickets to listen to the same sound twice with the same ear - enabling them to locate the sound's origin with pinpoint accuracy - has been demonstrated by scientists at the Universities of Lincoln and Bristol, UK.

 

HFSP Program Grant holder Mandyam Srinivasan and colleagues

Monday 23rd January 2017

High-speed video films of budgerigars flying through a tapered corridor reveal that these birds tend to fly at two distinct speeds: a high speed (approximately 10 m/s) for cruising in open environments, and a low speed (approximately 5 m/s) for maneuvering in cluttered environments [1].

 

HFSP Young Investigator Grant holder Kristian Franze and colleagues

Thursday 19th January 2017

For decades it was assumed that growing neurons find their way through the developing brain using chemical signals only. However, it turns out that neurons also 'feel' the stiffness of the tissue and that this is equally important for proper outgrowth.

 

HFSP Young Investigator Grant holder Gang Han and colleagues

Tuesday 17th January 2017

HFSP grant holder Gang Han and his team have designed a highly NIR-sensitive organic nanoparticle that is able to be operated with cost-effective low power lamp light to kill cancer tumors in deep tissue.

 

HFSP Career Development Award holder Georg Keller and colleagues

Tuesday 17th January 2017

Movements are directly coupled to sensory feedback: moving the eyes, head, or body results in predictable visual feedback. What we show is that in mouse visual cortex there is a system of neurons, parallel to the classical visual system, that selectively responds to deviations from the expected visual feedback resulting from movements.

 

HFSP Program Grant holders Fan Bai and Teuta Pilizota and colleagues

Tuesday 10th January 2017

Bacteria live and grow under significant osmotic pressure - the difference between osmolarity inside the cell and that of the environment. When placed in environments with low osmolarity, bacteria manage to stay in control of their pressure and cell volume by opening a hole in the membrane and responding to competition arising from a propensity of the water and intracellular molecules to enter or exit the cell.

 

HFSP Career Development Award holder Knut Drescher and colleagues

Thursday 5th January 2017

Bacteria in the environment often exist in communities, termed biofilms. In Escherichia coli biofilms, individual cells differ from one another with respect to many important physiological parameters. How this heterogeneity arises remains elusive, but an understanding of the extent to which it governs biofilm development is rapidly emerging.

 

HFSP Program Grant holders Benoit Ladoux, Chwee Teck Lim and René-Marc Mège and colleagues

Tuesday 3rd January 2017

Epithelial cells have a natural tendency to close gaps and this feature plays a crucial role in many biological processes such as embryological development, wound healing and apoptotic events. In the latter, the removal of cells in excess through extrusion is important to prevent accumulation of cells and tumor formation. The process can be triggered by multiple pathways that include apoptotic signaling, oncogenic transformation, and overcrowding of cells. Such events strongly depend on intercellular...