Awardees' Articles

HFSP Long-Term Fellow Marcus Wilson and colleagues

Tuesday 8th November 2016

DNA is under constant attack, which can cause unwanted genetic mutations and cancer. Luckily, our cells have a host of DNA repair proteins, which help to fix most of the damage. A new study takes a look at how 53BP1, a key DNA repair protein, is recruited to sites of DNA breaks.


HFSP Program Grant holders Ian Baldwin, Chung-Mo Park and Kyunghwan Oh and colleagues

Monday 7th November 2016

Roots monitor the aboveground light environment through root-photoreceptors for optimal growth and development.


HFSP Long-Term Fellow Tal Laviv and HFSP Program Grant holder Ryohei Yasuda and colleagues

Friday 4th November 2016

Researchers at the Max Planck Florida Institute for Neuroscience and Stanford University teamed up to develop a new molecular tag which allowed visualization of two signalling proteins' activity in a single dendritic spine in real time.


HFSP Long-Term Fellow Jeffrey Donlea and Program Grant holder Gero Miesenböck and colleagues

Thursday 27th October 2016

Sleep-promoting neurons switch between electrical activity and silence as a function of sleep need. The switch is operated by dopamine and involves the antagonistic regulation of two potassium channels.


HFSP Long-Term Fellow Kun Li and colleagues

Friday 21st October 2016

In humans, gender specific differences in the prevalence of emotional disorders have been observed. A new study reveals the circuit and molecular mechanism that is responsible for gender biases in the occurrence of social and anxiety related disorders.


HFSP Program Grant holder Cristina Lo Celso and colleagues

Thursday 20th October 2016

New research is shedding light on how leukaemia cells can survive cancer treatment, suggesting new possibilities for stopping them in their tracks. Intravital microscopy reveals that leukaemia cells are highly motile and do not associate with specific cellular structures of the bone marrow.


HFSP Long-Term Fellow Jérémie Barral and colleagues

Monday 17th October 2016

A salient feature of neuronal networks is the maintenance of balance between excitatory and inhibitory drives (E-I balance). Maintaining a balance of E and I inputs to neurons is crucial and severe imbalances can lead to excessive or insufficient activity that will degrade coding or produce neuropathologies such as epileptic seizures, autism spectrum and schizophrenic disorders. Over the past decade, several key theories have been developed that specify the conditions under which E-I balance may...


HFSP Cross-Disciplinary Fellow David Maresca and colleagues

Monday 10th October 2016

Ultrasound is among the most widely used biomedical imaging modalities, revealing babies' first pictures and helping diagnose disease. Yet ultrasound has limited ability to image specific molecular targets due to the lack of nanoscale contrast agents.


HFSP Cross-Disciplinary Fellow Yong Wang and colleagues

Tuesday 27th September 2016

A novel arrangement of bacterial plasmids was observed using advanced fluorescence microscopy, shedding light on how bacteria maintain plasmids of multi-copies and the associated antibiotic resistant genes.


HFSP Long-Term Fellow Maximilian Joesch and colleagues

Monday 26th September 2016

Neurons connect with each other to form complex circuits that underlie mental activities. Mapping these connections to obtain a so-called wiring diagram is an essential step in learning how the brain works. At present, the only way to do this precisely enough is by using electron microscopy. However, this technique is so time-consuming that thousands of hours of work are typically required to image and analyze even the smallest tissue samples. To overcome this limitation, we developed a pipeline...