Awardees' Articles

HFSP Program Grant holder Juan José Vaquero and colleagues

Friday 8th January 2016

Positron emission tomography (PET) imaging is an important clinical modality as well as a valuable tool in preclinical studies, mainly used in murine models of disease. However, the physics of the image formation limits the image resolution that can be achieved in in vivo experiments. The presented algorithm overcomes one of the most elusive limitations of the PET imaging technique, the positron range (PR) that precedes the generation of the gamma rays detected and used to reconstruct the image.

 

HFSP Cross-Disciplinary Fellow Sebastian Fürthauer and HFSP Program Grant holder Daniel Needleman and colleagues

Thursday 7th January 2016

To better understand important cellular structures we studied networks of stabilized microtubules in Xenopus egg extracts. We found that the molecular motor dynein organizes microtubules into networks of asters and generates large scale contractions by collecting microtubule minus ends.

 

HFSP Long-Term Fellow Matteo Rauzi and colleagues

Monday 4th January 2016

When tissue remodeling occurs during development, diverse cell shape changes take place at the same time at different positions in the embryo. Integrating cell properties and cell mechanics at the embryo scale enables understanding of how tissues coordinate and interact during development to sculpt the embryo.

 

HFSP Career Development Award holder Jan Huisken and colleagues

Monday 21st December 2015

With our new hyperspectral light sheet microscope we acquire the full emission spectrum in each pixel with nanometer resolution. Having the spectral information in hand, we resolved the signal of strongly overlapping dyes and fluorescent proteins and eliminated the autofluorescence signal in living zebrafish and drosophila embryos.

 

HFSP Program Grant holders Klaus Hahn, Haruo Kasai and Brian Kuhlman and colleagues

Friday 18th December 2015

We developed a genetically encoded probe that can label and optically erase synapses that were enlarged or generated by motor learning. Dense labeling of synapses was found in a small subset of pyramidal neurons, and irradiation with blue light erased motor memory.

 

HFSP Program Grant holders Joseph Corbo, Almut Kelber, Nicholas Roberts and colleagues

Saturday 12th December 2015

Whether they are discriminating a dazzling colorful mating display or navigating through a complex environment at high speeds, most birds rely on vision as their most important sensory modality. The importance of vision in the lives of birds is reflected in the sophistication of their photoreceptors, yet the functional significance of this complexity is not well understood. We have used a variety of advanced technologies to characterize the spectral filtering and optics of avian cone photoreceptors...

 

HFSP Long-Term Fellow Patrick Narbonne and colleagues

Tuesday 8th December 2015

Stem cell proliferation and differentiation rates in adult tissues are under the influence of systemically-released growth factors. These systemic signals are, however, bypassed in the C. elegans germ line upon accumulation of oocytes, the stem cells' terminally-differentiated progeny, thus highlighting a feedback mechanism that acts to locally control stem cell proliferation rates despite systemic information.

 

HFSP Program Grant holder Alfred Crosby and colleagues

Monday 7th December 2015

Hierarchical structures within natural materials are widely known to provide advantageous combinations of stiffness, toughness, and friction. The combination of polyampholyte hydrogels and woven fabrics offers an attractive route to taking advantage of multi-scale interactions and advantageous swelling histories to provide a new class of composite materials with properties that match those of wet biological tissues.

 

HFSP Long-Term Fellow Jirka Peschek and colleagues

Friday 4th December 2015

Cells adjust the protein folding capacity of the endoplasmic reticulum by a network of stress signaling pathways known as the unfolded protein response (UPR). The most conserved branch of the UPR relies on the cytoplasmic splicing of a specific mRNA. We identified an RNA zipper mechanism as a unique and conserved feature promoting this non-conventional splicing mechanism.

 

Program Grant holders Shigeru Kitazawa and Reza Shadmehr and colleagues

Tuesday 1st December 2015

While damage to the cerebellum can make control of movements very difficult, this report provides new evidence that even the damaged cerebellum has a latent mechanism of learning: it learns better when movement errors are kept small, but is quite impaired if the errors are large.