Awardees' Articles

HFSP Long-Term Fellow Darcie Moore and colleagues

Friday 16th October 2015

The ability of somatic stem cells to regenerate tissue is reduced with aging, resulting in effects such as cognitive impairment, reduced immune response, deterioration of skeletal muscle, and difficulty in wound healing. Using neural stem cells of the brain, the authors suggest the mechanism behind this age-dependent stem cell dysfunction is the cell's inability to segregate accumulated damage to its progeny during cell division due to a weakened diffusion barrier.

 

HFSP Young Investigator Grant holders Iain Cheeseman, Helder Maiato and Matthias Weiss and colleagues

Tuesday 13th October 2015

Mitotic entry in higher eukaryotes is always accompanied by fenestration of the nuclear envelope, allowing mitotic regulators to passively diffuse from the cytoplasm into the "nuclear" space and vice versa. Curiously, several of these proteins have been shown to accumulate in the "nuclear" region although a stationary binding substrate could not be identified. Our recent findings shed light on the underlying mechanism and reveal its importance for accurate cell division.

 

HFSP Young Investigator Grant holders Alessandra Cambi and Diane Lidke and colleagues

Monday 12th October 2015

A complex interplay between different cell types is needed to ensure the efficient response of the immune system. Communication between mast cells and dendritic cells reveals an unexpected role for mast cells in modulating the immune response.

 

HFSP Long-Term Fellow Owen Randlett and colleagues

Monday 12th October 2015

The larval zebrafish brain is small and accessible enough that it can be studied as a whole to determine how this entire brain generates behavior. Using high-throughput brain imaging and automated analyses, HFSP Long-Term Fellow Owen Randlett and colleagues have developed new methods to create and analyze brain-wide activity maps made from freely behaving zebrafish. By imaging over 1600 fish, they have identified areas in the brain that respond to various behavioural and pharmacological stimulations...

 

HFSP Long-Term Fellow Eric Geertsma and colleagues

Thursday 8th October 2015

The SLC26 proteins constitute a large family of anion transporters whose malfunctioning in humans is associated with diseases. We determined the first structure of a prokaryotic homolog that defines the common framework for the diverse functional behavior of the family.

 

HFSP Cross-Disciplinary Fellow Tsevi Beatus and colleagues

Monday 5th October 2015

Flies stabilize themselves during flight using a control reflex that is among the fastest in the animal kingdom. The findings described below are important for the basic understanding of animal locomotion and for the development of tiny flapping robots.

 

HFSP Long-Term Fellow Manuel Irimia and colleagues

Thursday 1st October 2015

The recent finding that dozens of highly conserved tiny microexons exist in our genes and show striking neuronal-specific regulation suggests that microexons play crucial roles in brain development and function. However, these roles are largely unknown. By knocking out the major regulator responsible for the neuronal-specific regulation of microexons, nSR100/SRRM4, we obtained insights into the biological functions of microexons in mammalian brain development. Misregulation of microexons is associated...

 

HFSP Long-Term Fellow Roberto J. Brea and colleagues

Monday 28th September 2015

The tools of synthetic biology could allow the reconstitution of the necessary machinery to create synthetic membranes, as well as the intracellular constituents to generate specific functions, enabling the efficient construction of artificial cells. Herein, we describe relevant aspects of the design and preparation of minimal supramolecular architectures that can faithfully mimic or reconstruct the structure and/or function of living cells. Additionally, we report the spontaneous reconstitution...

 

HFSP Long-Term Fellow Matteo Fumagalli and colleagues

Friday 25th September 2015

The Inuit, the natives of Greenland, and their ancestors have been living in the extreme conditions of the Arctic for thousands of years and have been exposed to both cold annual temperatures and a traditional high-fat diet. We discovered that the Inuit genome has mutations in genes controlling how fat is metabolized, allowing them to physically adapt on a diet rich in omega-3 polyunsaturated fatty acids from marine mammals.

 

Press release for HFSP Career Development Award holder Rune Linding and colleagues

Thursday 24th September 2015

Cancer Genomics: Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.