Awardees' Articles

HFSP Program Grant holders Daniel Forger, Hugh Piggins and Toru Takumi

Monday 14th September 2015

GABA is the only signal sent and received by all cells in the suprachiasmatic nucleus (SCN), the site of the central circadian pacemaker. We discovered separate and simultaneous mechanisms by which GABA in the SCN times fast electrical signals in cells, daily rhythms in the body and the time of year.

 

HFSP Young Investigator Grant holders Manuel Théry and Maxence Nachury and HFSP Program Grant holder Laurent Blanchoin and colleagues

Thursday 10th September 2015

A microfluidic device has been designed to attach and bend microtubules with hydrodynamic flows. Repeated sequences of microtubule bending revealed that microtubules soften under constraint but also that they could recover their stiffness by self-repairing.

 

HFSP Long-Term Fellow Romain Levayer and colleagues

Monday 7th September 2015

Cell competition is the mechanism that drives the elimination of slow proliferating cells (so called losers) by faster proliferating cells (winners) through apoptosis and can promote tumor expansion. By studying quantitatively cell competition through long term live imaging in Drosophila, we found that the probability of loser cell elimination correlates with the proportion of contact with winners and that winner cells actively mix with losers. The mixing increases the surface of contact between...

 

HFSP Program Grant holders Nick Melosh and Andreas Schaeffer and colleagues

Tuesday 1st September 2015

Electrical recordings of delivery of drugs inside cells is a cornerstone of modern biotechnology. However, how materials enter or penetrate the cell wall is still something of a mystery. We show a new technique that demonstrates the ability of different materials and surfaces to cause membrane rupture.

 

HFSP Long-Term Fellow Fernando García-Moreno and Program Grant holder Zoltán Molnár

Monday 31st August 2015

Understanding development and evolution of the neocortex has important implications. Differential timing of developmental events sculpts the brains of different species into distinct organs. The latest investigations on the development of the dorsal forebrain in chick and mouse embryos showed a major difference between vertebrate brains. A delay in the neurogenic properties of a subset of progenitors is specific to mammals and could be responsible for the evolutionary origin of the corpus callosum...

 

HFSP Young Investigator Grant holders Justin Seymour and Roman Stocker and colleagues

Tuesday 25th August 2015

Corals develop important beneficial, and sometimes detrimental, relationships with a range of microorganisms, including algae and diverse populations of bacteria and archaea, but little is currently known about the microbial behaviors involved in the establishment and maintenance of coral-microbe interactions. We applied a suite of approaches, including microfluidic experiments and genomic analysis, to investigate the extent to which natural communities of coral associated microbes use deliberate...

 

HFSP Program Grant holders René Marc Mège and Benoit Ladoux and colleagues

Monday 24th August 2015

Cadherins are the major component of adherens junctions, holding cells together by forming 'trans' interactions with cadherin molecules in the plasma membrane of adjacent cells. Crystal structures of cadherin indicate that the protein can also form 'cis' interactions with E-cadherin molecules in the same cell membrane, but whether these interactions help organize cadherin in vivo, and how this might affect the function of adherens junctions, remains unclear.

 

HFSP Career Development Award holder Jeroen Van Zon and colleagues

Tuesday 21st July 2015

It is an open question how, during embryonic development, spatial patterns of gene expression are induced with high precision. By counting single mRNA molecules during vulva induction in the nematode worm Caenorhabditis elegans, we established that the induced cells dynamically control the level of gene expression by increasing their sensitivity to the external inductive signal.

 

HFSP Young Investigator Grant holder Giovanni Pezzulo and colleagues

Monday 20th July 2015

Recent evidence challenges the traditional serial (decide-then-act) view of decision making, showing that decision and action processes can run in parallel. Here, we present a formal model in which decisions and actions are considered and optimized jointly, and apply it to various dynamical choice tasks. A prominent aspect of this model is an analysis of how action processes influence decision processes and not only vice-versa as often proposed.

 

HFSP Long-Term Fellow Simon Chen and HFSP Young Investigator Grant holder Takaki Komiyama

Tuesday 14th July 2015

Imagine when you are learning to play a long string of notes on a piano or to make a golf swing at a driving range, what is changing in your brain that allows you to learn those movements? The motor cortex in the brain has been shown to play an active role in the learning of new motor skills, and here we describe a specific type of inhibitory neuron in the motor cortex that is responsible for gating the changes required for the learning of new skilled movements.