Awardees' Articles

HFSP Long-Term Fellow Patrick Narbonne and colleagues

Tuesday 8th December 2015

Stem cell proliferation and differentiation rates in adult tissues are under the influence of systemically-released growth factors. These systemic signals are, however, bypassed in the C. elegans germ line upon accumulation of oocytes, the stem cells' terminally-differentiated progeny, thus highlighting a feedback mechanism that acts to locally control stem cell proliferation rates despite systemic information.

 

HFSP Program Grant holder Alfred Crosby and colleagues

Monday 7th December 2015

Hierarchical structures within natural materials are widely known to provide advantageous combinations of stiffness, toughness, and friction. The combination of polyampholyte hydrogels and woven fabrics offers an attractive route to taking advantage of multi-scale interactions and advantageous swelling histories to provide a new class of composite materials with properties that match those of wet biological tissues.

 

HFSP Long-Term Fellow Jirka Peschek and colleagues

Friday 4th December 2015

Cells adjust the protein folding capacity of the endoplasmic reticulum by a network of stress signaling pathways known as the unfolded protein response (UPR). The most conserved branch of the UPR relies on the cytoplasmic splicing of a specific mRNA. We identified an RNA zipper mechanism as a unique and conserved feature promoting this non-conventional splicing mechanism.

 

Program Grant holders Shigeru Kitazawa and Reza Shadmehr and colleagues

Tuesday 1st December 2015

While damage to the cerebellum can make control of movements very difficult, this report provides new evidence that even the damaged cerebellum has a latent mechanism of learning: it learns better when movement errors are kept small, but is quite impaired if the errors are large.

 

HFSP Long-Term Fellow Pavan Ramdya and colleagues

Tuesday 1st December 2015

The brain is never quiet. Activity fluctuations - or noise - impinge upon all neural circuits and may therefore have an important effect on decision-making. A former HFSP Long-Term Fellow, Pavan Ramdya, and colleagues explored this possibility by generating and studying noise-driven artificial neural networks that are able to mimic the unpredictable timing of fruit fly walking behaviors.

 

HFSP Long-Term Fellow Einat Segev and colleagues

Monday 30th November 2015

Roseobacters are a group of marine bacteria that interact with many different hosts in the ocean. Various Roseobacters are capable of physically attaching to their hosts, to each other and to various surfaces. A key question is how do these bacteria attach?

 

HFSP Long-Term Fellow Eirini Kaiserli and colleagues

Friday 27th November 2015

Flowering is controlled by multiple environmental stimuli. A new signal-integrating component of light and photoperiodic signalling is recruited to nuclear photobodies to regulate the transcriptional activation of flowering time in Arabidopsis thaliana.

 

HFSP Long-Term Fellow Iain Mathieson and colleagues

Thursday 26th November 2015

Ancient DNA makes it possible to observe natural selection directly by looking for parts of the genome that changed rapidly over time. By sequencing the genomes of ancient Europeans who lived during the past eight thousand years, we find selection on genes associated with diet, pigmentation and immunity, likely driven by the transition to an agricultural lifestyle in new environments at this time.

 

HFSP Cross-Disciplinary Fellow Kurt Schmoller and HFSP Long-Term Fellow Mardo Kõivomägi and colleagues

Tuesday 24th November 2015

Many cells, including the unicellular organism budding yeast, control their own size by linking growth and division. Now, a molecular mechanism that allows budding yeast to measure and adjust its own size has been identified.

 

HFSP Young Investigator Grant holder Rosalind Allen and colleagues

Monday 23rd November 2015

We have tracked how bacteria compete for space when they grow on a surface, using a microscope and computer simulations. The "winners" of this ecological competition depend on both the speed at which bacteria colonize the space around them and the interactions between competing populations when they collide.