Awardees' Articles

HFSP Program Grant holders Melissa Little and Ian Smyth and colleagues

Monday 8th October 2018

Branching morphogenesis is an ancient process integral to the development of many organs; however, the extent to which it shares features between organs is unclear. We found distinct differences in how the kidney and the mammary gland elaborate, which do not support previous claims for the existence of a unifying theory of branching morphogenesis.

 

HFSP Program Grant holder Maria Garcia-Parajo and colleagues

Thursday 4th October 2018

A new microscopy approach for simultaneous multicolour imaging with single molecule sensitivity has been developed in the Garcia-Parajo lab.

 

HFSP Long-Term Fellow Omer Ziv and colleagues

Monday 1st October 2018

RNA viruses use multiple strategies to enhance the functional capacity of their small genomes. This study reports on a new technique to determine the structure of viral RNA genomes while replicating inside human cells and to explore how viruses interact with the host's own RNA. It reveals the dynamic nature of the Zika virus genome and enables new strategies to interfere with the virus infectious cycle to be designed.

 

HFSP Program Grant holder Kenneth Welch and colleagues

Friday 28th September 2018

Unlike most vertebrates, hummingbird flight muscle expresses transcripts that encode proteins that enable high transport and oxidation capacity for not just glucose, but fructose as well. This suggests the cellular physiology of hummingbird muscles is specialized to efficiently extract energy from their unusual fructose-rich diet.

 

HFSP Long-Term Fellow Arpan Kumar Rai and colleagues

Tuesday 11th September 2018

The mechanism of how many of the membraneless organelles (MLOs) inside cells undergo complete dissolution when cells enter mitosis and re-condense back upon mitotic exit is not well understood. This study shows that dilution of proteins upon nuclear envelope breakdown and the kinase activity of a dual specificity kinase (DYRK3) is required for mitotic dissolution of several MLOs. This is followed by degradation of DYRK3 by anaphase promoting complex during mitotic exit, aiding MLO re-condensation...

 

HFSP Long-Term Fellow Uri Ben-David and colleagues

Monday 10th September 2018

Cancer cell lines are the backbone of cancer research. In this study, Ben-David and colleagues found that the genetic diversity across multiple samples of the same cancer cell line was much higher than previously appreciated. Anticancer drugs that efficiently kill a cell line in one lab may be completely useless against the same cell line cultured in another lab.

 

HFSP Career Development Award holder Magdalini Polymenidou and colleagues

Thursday 9th August 2018

The RNA-binding protein FUS, which localizes to the nucleus of normal neurons, forms cytoplasmic aggregates in a subset of patients with early onset frontotemporal dementia (FTD-FUS), via an uncharacterized mechanism. This study investigates the role of hypertonic stress in the initiation of FUS pathology and describes a new molecular mechanism active in neurons, but not astrocytes, which may contribute to the neuronal dysfunction in FTD-FUS patients.

 

HFSP Long-Term Fellow Kenji Sugioka and colleagues

Tuesday 7th August 2018

During animal development, cell division orientations are arranged in diverse angles to shape tissue and organs, but the mechanism to orchestrate the division axis diversity remains unknown. In this study, Sugioka and Bowerman found that different combinations of contact-dependent cues specify multiple cell division axes by directing a flow of myosin at the cell surface.

 

HFSP Career Development Award holder Pablo Manavella and colleagues

Monday 6th August 2018

A nuclear inactive reserve pool of the micro RNA biogenesis factor HYL1, in a phosphorylated state, is specifically protected inside the nucleus from dark/shade-induced degradation. Upon light restoration, this reserve pool is quickly dephosphorylated to rapidly restore miRNA production and switch the developmental program to light dependent growth.

 

HFSP Career Development Award holder Maximilian Fürthauer and colleagues

Thursday 19th July 2018

The characterization of a unifying mechanism governing left-right asymmetry in different phyla has long remained elusive. We show that Myosin1D, a previously identified regulator of Drosophila left-right asymmetry, is essential for the formation and function of the zebrafish left-right organizer, identifying thereby an evolutionarily conserved regulator of animal laterality.