Awardees' Articles

HFSP Program Grant holder Ian Baldwin and colleagues

Thursday 25th January 2018

Plants can effectively get rid of herbivores by "calling for help" using odors which attract animals that eat herbivores; but herbivores feed on plants day and night, and may try to escape danger by choosing to feed when their enemies are not active. By producing a combination of rapidly and slowly released odors, both of which are attractive to herbivores' enemies, plants can always "call for help" at the right time, regardless of when herbivores feed.

 

HFSP Program Grant holders Marcus Conrad, Valerian Kagan, Judith Klein-Seetharaman and Fulvio Ursini and colleagues

Tuesday 16th January 2018

Multicellular life developed genetically determined programs for the elimination of irreparably injured cells. While apoptosis has been in the focus of cell death for many years, the recognition that cells with accumulated excessive levels of (geno)toxic materials also die by regulated necrotic cell death routines has sparked great interest among researchers and drug makers. The latest addition to the list of these cell death programs is ferroptosis - a network of reactions engaging three major...

 

HFSP Program Grant holders Valentina Emiliani and Ed Boyden and colleagues

Monday 15th January 2018

A new approach that allows the spatial and temporal control of neuronal activation at a single cell level with a resolution of the order of milliseconds has been developed in the labs of HFSP grant holders Valentina Emiliani and Ed Boyden. This approach combines the development of a new type of light-sensitive protein that can be embedded in neuron cell bodies, combined with an innovative holographic light shaping approach that can focus light on a single cell using low light levels. These advances...

 

HFSP Long-Term Fellow Ryosuke Kojima and colleagues

Thursday 4th January 2018

Designer non-immune cells that mimic T-cell functions without the risks associated with engineered immune cells have been developed. The designer cells might become useful for next-generation cell-based cancer therapy. This study also extends available design principles to create artificial cellular functions.

 

HFSP Long-Term Fellow Erinc Hallacli and colleagues

Tuesday 2nd January 2018

Proteins fold into elaborate structures to execute their functions, and failure to do so causes many diseases, including neurodegenerative Alzheimer's disease and Parkinson's disease. However, cells can also use protein aggregation to their benefit, forming compartmentalized membrane-less bodies. Tracking these elaborate folding behaviors of proteins has been a challenge. We have developed a simple, yet powerful, tool to track protein folding in the cell with minimal observer interference...

 

HFSP Program Grant holders Abderrahmane Kaidi, Robert Grosse, Kei Miyamoto and colleagues

Friday 15th December 2017

When cells divide, they need to rebuild their nuclei and organise their genome. New HFSP-funded collaborative research reveals how cells achieve this through the unexpected involvement of filamentous actin (F-actin) inside the nucleus.

 

HFSP Program Grant holder Douglas Altshuler and colleagues

Thursday 14th December 2017

Hummingbirds must maintain contact with flowers in order to collect nectar, which can be challenging when flowers or background vegetation move in the wind. How do hummingbirds control their flight to feed in a moving environment? In experimental scenarios where either the feeder or the visual background moves, hummingbirds fly to maintain body position relative to the background, instead of flying to track the position of the feeder.

 

HFSP Long-Term Fellow Kenzo Ivanovitch and colleagues

Tuesday 12th December 2017

Live 3D imaging analysis reveals the coordination that occurs between cardiac progenitor cells - cells that, similar to stem cells, can change into another specific type of cell - during heart development. We found that progenitor cells go through alternate phases of changing into cardiac muscle (differentiation) to help initiate early heart function, and assisting the heart tube to take on its shape (morphogenesis).

 

HFSP Cross-Disciplinary Fellow Philippe Roudot and colleagues

Tuesday 28th November 2017

In fluorescent imaging, the study of intracellular dynamics is often challenged by the fast and heterogeneous motions of particles that results in the imaging of unpredictable transitions in a dense field of particle displacement. We designed a new algorithm that interrogates multiple motion types in forward and backward temporal directions in a rigorous statistical framework and found that in addition to improving the tracking of heterogeneous dynamics, our method requires lower acquisition frequency...

 

HFSP Young Investigator Grant holders Diego Oyarzún and Fuzhong Zhang and colleagues

Tuesday 7th November 2017

Mathematical modeling and wet-lab engineering revealed how genetic tuning shapes biosensor function. Our findings enable precision engineering of gene circuits for basic science and microbial cell factories.