Awardees' Articles

HFSP Program Grant holder David Lentink and colleagues

Friday 20th November 2015

HFSP Program Grant awardee David Lentink and his colleagues have developed a novel suspension system for in-flight cameras using whooper swan flight as a cue for their latest tech tool. The development of this new tool is an essential element in an HFSP funded collaboration with colleagues in Australia and Canada to understand the exquisite flight control mechanisms of birds because they exhibit complex and diverse flight, and naturally fly over regions typically not easily accessible to controlled...


HFSP Long-Term Fellow Caspar Schwiedrzik and HFSP Program Grant holder Winrich Freiwald and colleagues

Thursday 19th November 2015

Studying the connectivity of face processing areas in monkeys reveals the routes by which information about faces is exchanged with other brain areas supporting socially, emotionally, and cognitively relevant functions, and uncovers a set of brain areas stunningly similar to the network implementing high-level social cognition in humans.


HFSP Career Development Award holder Pablo Manavella and colleagues

Tuesday 17th November 2015

MicroRNAs (miRNAs) are key regulators of plant development. These small molecules are produced by a dynamic but highly coordinated process. The processing of miRNA is carried out by a group of well-characterized proteins. Despite the handful of cofactors regulating this process that have been identified in recent years, it is unclear how the plant fine-tunes the production of miRNA in different tissues. Now, RCF3 was identified as a regulator of the miRNA processing machinery acting preferentially...


HFSP Long-Term Fellow Yonatan Stelzer and colleagues

Monday 16th November 2015

DNA methylation is considered a key epigenetic modification that shapes and maintains cellular identity. In recent years, advancements in sequencing technologies enabled the generation of detailed single-base resolution maps of DNA methylation in multiple cell types. However, current methods only provide a static "snapshot" of the methylation levels thus precluding the study of real-time epigenetic changes and limiting prospective mechanistic experiments. Here, we established a novel reporter...


HFSP Program Grant holder Uri Alon and colleagues

Friday 13th November 2015

Newly developed technologies enable the expression of many genes in single cells to be measured, thus posing the challenge of analyzing and understanding this high-dimensional data. A recent theory on multi-objective task optimization suggests that this data should be arranged in simple geometrical shapes. Applying this theory allows the tasks and the trade-offs that the tissue faces to be revealed.


HFSP Young Investigator Grant holders Kristian Franze, Malte Gather and Giuliano Scarcelli and colleagues

Tuesday 10th November 2015

Although microglial cells, which represent the first line of immune defense in the central nervous system, constantly mechanically interact with their environment, our current understanding of microglia mechanics is very limited. Here, we quantified forces exerted by healthy and activated microglial cells, investigated how mechanical signals impact their migration patterns, developed a theoretical framework to predict their mechanical behavior, and found that immune activation decreases microglial...


HFSP Young Investigator Grant holder Harald Janovjak and colleagues

Tuesday 3rd November 2015

Many biological questions are answered by systematically 'screening' experimental conditions, such as different genetic make-ups of organisms, environmental parameters or drug candidates. Light is at the heart of a new method that radically reduces complexity in and simplifies design of biological high-throughput screens.


HFSP Career Development Award holder Patrick Müller and HFSP Program Grant holder Alexander Schier and colleagues

Monday 2nd November 2015

Protein degradation governs many biological processes, but studying degradation can be technically challenging. We developed a degradation assay and a software package that overcome several of these challenges.


HFSP Program Grant holder Yamuna Krishnan and colleagues

Tuesday 27th October 2015

Synthetic DNA-based nanodevices offer tremendous promise as drug delivery capsules and diagnostic tools in living systems. In a recent perspective (Surana et al. Nat. Nanotechnol. 2015), we outline possible outcomes of the interactions between DNA nanostructures and the immune system, and envision potential design principles in these architectures to circumvent the multifaceted defense machinery of higher organisms.


HFSP Long-Term Fellow Franz Weber and colleagues

Monday 26th October 2015

Activation of GABAergic neurons in the ventral medulla can reliably induce REM sleep, the brain state associated with vivid dreaming.