Awardees' Articles

HFSP Long-Term Fellow Owen Randlett and colleagues

Monday 12th October 2015

The larval zebrafish brain is small and accessible enough that it can be studied as a whole to determine how this entire brain generates behavior. Using high-throughput brain imaging and automated analyses, HFSP Long-Term Fellow Owen Randlett and colleagues have developed new methods to create and analyze brain-wide activity maps made from freely behaving zebrafish. By imaging over 1600 fish, they have identified areas in the brain that respond to various behavioural and pharmacological stimulations...

 

HFSP Long-Term Fellow Eric Geertsma and colleagues

Thursday 8th October 2015

The SLC26 proteins constitute a large family of anion transporters whose malfunctioning in humans is associated with diseases. We determined the first structure of a prokaryotic homolog that defines the common framework for the diverse functional behavior of the family.

 

HFSP Cross-Disciplinary Fellow Tsevi Beatus and colleagues

Monday 5th October 2015

Flies stabilize themselves during flight using a control reflex that is among the fastest in the animal kingdom. The findings described below are important for the basic understanding of animal locomotion and for the development of tiny flapping robots.

 

HFSP Long-Term Fellow Manuel Irimia and colleagues

Thursday 1st October 2015

The recent finding that dozens of highly conserved tiny microexons exist in our genes and show striking neuronal-specific regulation suggests that microexons play crucial roles in brain development and function. However, these roles are largely unknown. By knocking out the major regulator responsible for the neuronal-specific regulation of microexons, nSR100/SRRM4, we obtained insights into the biological functions of microexons in mammalian brain development. Misregulation of microexons is associated...

 

HFSP Long-Term Fellow Roberto J. Brea and colleagues

Monday 28th September 2015

The tools of synthetic biology could allow the reconstitution of the necessary machinery to create synthetic membranes, as well as the intracellular constituents to generate specific functions, enabling the efficient construction of artificial cells. Herein, we describe relevant aspects of the design and preparation of minimal supramolecular architectures that can faithfully mimic or reconstruct the structure and/or function of living cells. Additionally, we report the spontaneous reconstitution...

 

HFSP Long-Term Fellow Matteo Fumagalli and colleagues

Friday 25th September 2015

The Inuit, the natives of Greenland, and their ancestors have been living in the extreme conditions of the Arctic for thousands of years and have been exposed to both cold annual temperatures and a traditional high-fat diet. We discovered that the Inuit genome has mutations in genes controlling how fat is metabolized, allowing them to physically adapt on a diet rich in omega-3 polyunsaturated fatty acids from marine mammals.

 

Press release for HFSP Career Development Award holder Rune Linding and colleagues

Thursday 24th September 2015

Cancer Genomics: Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.

 

HFSP Program Grant holders Daniel Forger, Hugh Piggins and Toru Takumi

Monday 14th September 2015

GABA is the only signal sent and received by all cells in the suprachiasmatic nucleus (SCN), the site of the central circadian pacemaker. We discovered separate and simultaneous mechanisms by which GABA in the SCN times fast electrical signals in cells, daily rhythms in the body and the time of year.

 

HFSP Young Investigator Grant holders Manuel Théry and Maxence Nachury and HFSP Program Grant holder Laurent Blanchoin and colleagues

Thursday 10th September 2015

A microfluidic device has been designed to attach and bend microtubules with hydrodynamic flows. Repeated sequences of microtubule bending revealed that microtubules soften under constraint but also that they could recover their stiffness by self-repairing.

 

HFSP Long-Term Fellow Romain Levayer and colleagues

Monday 7th September 2015

Cell competition is the mechanism that drives the elimination of slow proliferating cells (so called losers) by faster proliferating cells (winners) through apoptosis and can promote tumor expansion. By studying quantitatively cell competition through long term live imaging in Drosophila, we found that the probability of loser cell elimination correlates with the proportion of contact with winners and that winner cells actively mix with losers. The mixing increases the surface of contact between...