Awardees' Articles

HFSP Cross-Disciplinary Fellow Ana Amador and colleagues

Thursday 27th February 2014

Fundamental unresolved problems of motor coding and sensorimotor integration include what information about behavior is represented at different levels of the motor pathway. An interdisciplinary collaboration integrating physical, acoustic, and biological approaches validated a dynamical systems model for birdsong production and proposed a novel frame for understanding neural coding in zebra finches.

 

HFSP Program Grant holders Gohta Goshima and Marcel Janson and colleagues

Monday 24th February 2014

MAP65 family proteins function as microtubule cross-linking proteins, and localise to the phragmoplast equator in the moss Physcomitrella patens (phragmoplast is a microtubule-based bipolar structure that appeared at the late stage of mitosis in plant cells). RNAi-mediated knockdown of MAP65s compromised microtubule bipolarity and affected accumulation and/or fusion of cell plate–destined vesicles at the equatorial plane.

 

HFSP Young Investigator Grant holders Rafael Carazo-Salas, Attila Csikasz-Nagy and Masamitsu Sato and colleagues

Thursday 13th February 2014

Everybody is talking about interdisciplinarity these days but how do we provoke it? In the current issue of the journal eLife, our HFSP funded Young Investigator team describes a computational speed-dating approach that we developed to purposely ‘engineer’ such interactions amongst participants in small scientific conferences which we successfully prototyped at a Royal Society Scientific Discussion Meeting, organized by means of our HFSP collaboration.

 

HFSP Career Development Award holder Marcelo Nollmann and Young Investigator Grant holder Tam Mignot and colleagues

Tuesday 11th February 2014

A new method that couples microfluidics and super-resolution microscopy to image live bacteria at unsurpassed spatial and temporal resolutions has been developed. Uniquely, this technology considerably improves cell stability, allows for long time-lapse imaging and completely eliminates chromatic aberrations.

 

HFSP Long-Term Fellow Martin Loose and colleagues

Monday 10th February 2014

For a long time it was assumed that a cytoskeleton would be exclusive to eukaryotes. However, proteins related to actin and tubulin also exist in bacteria, where they provide key structural components coordinating a number cellular functions.

 

HFSP Young Investigator Grant holders Roman Stocker and Justin Seymour and colleagues

Friday 7th February 2014

Coral reefs are threatened by disease. Using microfluidics and video microscopy to spy on the behavior of a coral pathogen, we discovered that it follows gradients of chemical cues leaking from the coral surface and responds more strongly to those coming from heat-stressed hosts.

 

HFSP Young Investigator Grant holder Ulrike Eggert and colleagues

Thursday 6th February 2014

Organisms use different types of biological building blocks to perform and regulate all of their functions. These building blocks, which include major biological molecules such as DNA, proteins and lipids, are assembled into cells and variations in their composition and localization are the basis for all biological processes. While biologists have a relatively good general understanding of how DNA and proteins work, we know very little about the functions of lipids.

 

HFSP Young Investigator Grant holders Monica Daley and Jonathan Hurst and colleagues

Monday 3rd February 2014

Robotic technologies have experienced a renaissance in recent years— yet the best humanoid robots remain far less capable of dynamic balance compared to humans and animals. We have discovered a simple control principle, inspired from running guinea fowl, which may help bipedal robots achieve the robust and agile athletic performance of these remarkable animals.

 

HFSP Long-Term Fellows Andrea Pauli and Eivind Valen and colleagues

Tuesday 28th January 2014

It has been assumed that most if not all signals that control early development are known. However, using genomics studies we identified several new candidate signals. We find that one of these - Toddler/Apela - is essential for embryogenesis by promoting the movement of cells during zebrafish gastrulation. Toddler/Apela signals through G-protein coupled receptors and might be the first in a series of previously uncharacterized developmental signals.

 

HFSP Long-Term Fellow Noam Kaplan and colleagues

Monday 27th January 2014

Although DNA sequencing technologies have advanced immensely in recent years, a typical published genome sequence may be fragmented in as many as 100,000 DNA fragments, due to the fact that full assembly of chromosomes is extremely difficult. We show how a simple genome-wide measurement of DNA 3D structural properties can be used to easily assemble and complete genome sequences in high-throughput for the first time.