Awardees' Articles

HFSP Long-Term Fellow Raunak Sinha and colleagues

Tuesday 14th March 2017

Our central vision is unable to detect rapidly changing visual inputs, such as flickering light, as well as our peripheral vision can. Where does this common perceptual difference originate in the visual system and what are the underlying neural mechanisms? We explored the cellular and circuit mechanisms in foveal and peripheral retina and unexpectedly uncovered that the perceptual difference in temporal sensitivity originates in the cone photoreceptors that transduce photons to electric signals...

 

HFSP Long-Term Fellow Kalyan Sinha and colleagues

Monday 13th March 2017

For a long time, it has not been possible to detect structural changes within the histone octamer core of a nucleosome due to limitations of the methods in use. In this study, using site-specific methyl-labeling and high-resolution NMR spectroscopy, we provide evidence of the existence of functionally important distortion of the octamer core in the presence of an ATP-dependent remodeling enzyme SNF2h.

 

HFSP Young Investigator Grant holders Tatiana Korotkova and Denis Burdakov and colleagues

Friday 10th March 2017

Food seeking is a complex behavior, crucial for survival. We identified a novel top-down pathway from medial prefrontal cortex to the lateral hypothalamus, which utilizes gamma synchronization to regulate food seeking by dynamic reorganization of functional cell groups in the hypothalamus.

 

HFSP Cross-Disciplinary Fellow Philip Bittihn and colleagues

Thursday 9th March 2017

Mutations in laboratory populations of simple organisms such as bacteria are of central interest in the context of experimental evolution and a major concern for bioengineers whose goal it is to equip them with evolutionarily stable added functionality. This study shows that the changes in population size as they are imposed by common experimental protocols can have a strong impact on the likeliness for mutations to spread through the population and makes quantitative predictions how the spectrum...

 

HFSP Long-Term Fellow Mariaceleste Aragona and colleagues

Tuesday 7th March 2017

One of the key questions in biology is to identify how tissues are repaired after trauma and understand how stem cells migrate, proliferate, and differentiate to repair tissue damage. We identified the cellular and molecular mechanisms that regulate wound healing in the skin.

 

HFSP Cross-Disciplinary Fellow Shalin Mehta and colleagues

Monday 6th March 2017

Directed functions of cells emerge from the nanoscale alignment of dynamic molecules. We have developed a new microscope and computational algorithms to analyze the alignment and orientation of dynamic biomolecules in live cells.

 

HFSP Program Grant holders Gohta Goshima and Marcel Janson and colleagues

Friday 3rd March 2017

How do cells define where they divide? The midbody in animals and the phragmoplast in plants are bipolar microtubule networks that coordinate cytokinesis. De Keijzer et al. demonstrate that the kinesin-4 dependent length of microtubule overlap zones in phragmoplasts confines the site of membrane deposition for septum formation.

 

HFSP Program Grant holders Joseph Corbo, Almut Kelber and Nicholas Roberts and colleagues

Thursday 2nd March 2017

Birds use four cone types to see the world in sparkling colours but this comes at a cost: colours fade away faster in dim light. Pooling signals from multiple cones helps them to still see colour, if only, with less detail.

 

HFSP Program Grant holders Andreas Plückthun and Gerhard Wagner and colleagues

Tuesday 28th February 2017

Membrane proteins play numerous biological roles, such as in signal transduction and viral entry, and are important drug targets. We engineered covalently circularized protein belts that can be used to stabilize patches of phospholipid bilayers, which provide a well-defined, extremely stable and near-native environment for the study of membrane proteins.

 

HFSP Long-Term Fellow Ella Preger-Ben Noon and colleagues

Monday 27th February 2017

Transcriptional systems exhibit extraordinary robustness. It is, therefore, unclear how such robust systems can evolve loss of expression through point mutations to cause evolutionary change. By deciphering the evolved regulatory changes in a robust enhancer of the shavenbaby gene, we discovered that gain of a repressor binding site can overcome transcriptional robustness encoded by multiple activator binding sites and contributes to morphological evolution.