Awardees' Articles

HFSP Long-Term Fellow Jennifer Fish and colleagues

Monday 31st March 2014

Because of high functional demands, tissue size is tightly regulated during development. This is particularly evident in limb length, where differences in size between matching limbs could have significant impacts on fitness. Although right and left sides of the body develop independently, right and left limbs consistently reach comparable length (Allard & Tabin 2009). Similarly, size differences in the right and left sides of the jaw are involved in many craniofacial malformations, such as...


HFSP Long-Term Fellow Hansong Ma and colleagues

Monday 24th March 2014

By generating various Drosophila lines with two mitochondrial genotypes, we show that purifying selection drove complete replacement of the deleterious mutations by a wild type genome, but selection can stabilize propagation of two defective genomes that are complementary. Interestingly, such a selection does not occur at the organismal level, but rather occurs during a confined stage of oogenesis, likely due to a preferential proliferation advantage of the co-existing genome, which is more functional...


HFSP Career Development Award holder Hervé Seitz and colleagues

Friday 21st March 2014

It is proposed that MicroRNAs regulate the expression of many target genes, suggesting they act as master regulators of the genome. We found that the Cnidarian Nematostella vectensis expresses dozens of different microRNAs (contradicting previous claims linking the number of microRNA genes to a poorly-defined "organism complexity") and we saw that Cnidarian microRNAs frequently direct endonucleolytic cleavage of their RNA targets, similarly to what is observed in plants.


HFSP Cross-Disciplinary Fellow Kimberly Bonger and colleagues

Thursday 13th March 2014

Methods to reversibly regulate protein levels in cells are valuable for researchers in life science. A technology to induce degradation of a protein of interest by blue light has been developed and applied in cells and zebrafish embryos.


HFSP Cross-Disciplinary Fellow Ana Amador and colleagues

Thursday 27th February 2014

Fundamental unresolved problems of motor coding and sensorimotor integration include what information about behavior is represented at different levels of the motor pathway. An interdisciplinary collaboration integrating physical, acoustic, and biological approaches validated a dynamical systems model for birdsong production and proposed a novel frame for understanding neural coding in zebra finches.


HFSP Program Grant holders Gohta Goshima and Marcel Janson and colleagues

Monday 24th February 2014

MAP65 family proteins function as microtubule cross-linking proteins, and localise to the phragmoplast equator in the moss Physcomitrella patens (phragmoplast is a microtubule-based bipolar structure that appeared at the late stage of mitosis in plant cells). RNAi-mediated knockdown of MAP65s compromised microtubule bipolarity and affected accumulation and/or fusion of cell plate–destined vesicles at the equatorial plane.


HFSP Young Investigator Grant holders Rafael Carazo-Salas, Attila Csikasz-Nagy and Masamitsu Sato and colleagues

Thursday 13th February 2014

Everybody is talking about interdisciplinarity these days but how do we provoke it? In the current issue of the journal eLife, our HFSP funded Young Investigator team describes a computational speed-dating approach that we developed to purposely ‘engineer’ such interactions amongst participants in small scientific conferences which we successfully prototyped at a Royal Society Scientific Discussion Meeting, organized by means of our HFSP collaboration.


HFSP Career Development Award holder Marcelo Nollmann and Young Investigator Grant holder Tam Mignot and colleagues

Tuesday 11th February 2014

A new method that couples microfluidics and super-resolution microscopy to image live bacteria at unsurpassed spatial and temporal resolutions has been developed. Uniquely, this technology considerably improves cell stability, allows for long time-lapse imaging and completely eliminates chromatic aberrations.


HFSP Long-Term Fellow Martin Loose and colleagues

Monday 10th February 2014

For a long time it was assumed that a cytoskeleton would be exclusive to eukaryotes. However, proteins related to actin and tubulin also exist in bacteria, where they provide key structural components coordinating a number cellular functions.


HFSP Young Investigator Grant holders Roman Stocker and Justin Seymour and colleagues

Friday 7th February 2014

Coral reefs are threatened by disease. Using microfluidics and video microscopy to spy on the behavior of a coral pathogen, we discovered that it follows gradients of chemical cues leaking from the coral surface and responds more strongly to those coming from heat-stressed hosts.