Awardees' Articles

HFSP Long-Term Fellow Sergi Regot and colleagues

Friday 20th June 2014

Single cells are intrinsically noisy and need to be analyzed individually. We describe a novel generalizable method to measure multiple kinase activities simultaneously in live single cells. Our technology opens the exciting possibility of dynamically analyzing multiple signaling networks, as well as cell cycle and a wide range of kinase mediated processes simultaneously at the single-cell level.


HFSP Long-Term Fellow Hans-Henning Kunz and colleagues

Thursday 22nd May 2014

Photosynthesis is the key biochemical reaction in plants but the molecular mechanisms of K+ transport across chloroplast membranes and their relevance for chloroplast function and photosynthesis remained unknown. We have identified and characterized three K+/ H+ transporters in chloroplast membranes and demonstrate their vital role for chloroplast osmoregulation and thylakoid density and photosynthesis. Surprisingly, high Na+ restored the photosynthetic activity in the mutant plants.


HFSP Long-Term Fellow Stephan Preibisch and HFSP Young Investigator Grant holder Pavel Tomancak and colleagues

Monday 19th May 2014

Modern light-sheet fluorescence microscopy is capable of imaging the development of an entire specimen at cellular level with high temporal resolution and provides unique opportunities for the observation of the same specimen from multiple angles (views). Deconvolution, a computational post-processing technique, can significantly increase spatial resolution of such datasets, but processing times are prohibitively long for large acquisitions. We developed a new multi-view deconvolution algorithm...


HFSP Young Investigator Grant holders Marco Cosentino Lagomarsino, Pietro Cicuta, and Bianca Sclavi and colleagues

Thursday 15th May 2014

Biophysical tools are increasingly providing key insights into understanding genome organisation in bacterial cells. We demonstrated the use of two complementary techniques, using manipulation by optical tweezers and high-throughput resistive pulse based sensing in micro-capillaries, to size individual bacterial genomes in a label-free manner.


HFSP Long-Term Fellow Ulises Rosas and colleagues

Tuesday 13th May 2014

How do plants know when to start flowering? What are the mechanisms underlying flowering diversity? We identified a natural polymorphism in CONSTANS, a regulatory gene controlling the flowering time developmental transition in Arabidopsis. We found that the polymorphism in CONSTANS controls transcriptional variation and flowering time diversity in Arabidopsis thaliana populations. This is one of the few natural regulatory polymorphisms known in Arabidopsis and other plants to be widely spread in...


HFSP Long-Term Fellow Fumi Kubo and colleagues

Friday 9th May 2014

During locomotion, the visual system is challenged by continuous movement of the visual scene that sweeps over the retina. How do animals sense and correct for visual motion during locomotion? We have identified various types of neurons that respond to visual motions, some of which might act as candidate circuit components to drive different compensatory behaviors.


HFSP Long-Term Fellow Conor McMeniman and colleagues

Thursday 8th May 2014

Have you ever been bothered by a mosquito? Lab generated mutant yellow fever mosquitoes were used to show that these insects are driven to find and bite humans by detecting combinations of carbon dioxide (CO2), heat, and odor that emanate from the human body.


HFSP Program Grant holders Philip Bevilacqua and Sarah Assmann and colleagues

Monday 28th April 2014

We developed a new approach to map the structure of RNA across the entire genome of any living organism. Our application of this method to the model plant Arabidopsis thaliana revealed novel insights into RNA splicing, alternative polyadenylation, translation, and RNA structure-function relationships.


HFSP Long-Term Fellow Michael Krieg and colleagues

Friday 25th April 2014

Forces are a ubiquitous challenge to all cells of our body and a protective mechanism has to be present. Some of the cells in our body have specifically evolved to detect these forces and convert mechanical energy into electrical signals that elicit an appropriate behavior. How they are able to withstand such mechanical insult without physical damage, while remaining sensitive enough to the stimulus to sense it, is not fully understood. Using the touch receptor neurons (TRNs) of C elegans as a model...


HFSP Long-Term Fellow Bungo Akiyoshi and Program Grant holder Keith Gull and colleagues

Thursday 24th April 2014

The kinetochore is the macromolecular protein complex that drives chromosome segregation in eukaryotes. Although it was widely assumed that the core kinetochore consists of proteins that are common to all eukaryotes, we found that the evolutionarily distant kinetoplastids build kinetochores using a novel set of proteins.