Awardees' Articles

HFSP Career Development Award holder Marcelo Nollmann and Young Investigator Grant holder Tam Mignot and colleagues

Tuesday 11th February 2014

A new method that couples microfluidics and super-resolution microscopy to image live bacteria at unsurpassed spatial and temporal resolutions has been developed. Uniquely, this technology considerably improves cell stability, allows for long time-lapse imaging and completely eliminates chromatic aberrations.

 

HFSP Long-Term Fellow Martin Loose and colleagues

Monday 10th February 2014

For a long time it was assumed that a cytoskeleton would be exclusive to eukaryotes. However, proteins related to actin and tubulin also exist in bacteria, where they provide key structural components coordinating a number cellular functions.

 

HFSP Young Investigator Grant holders Roman Stocker and Justin Seymour and colleagues

Friday 7th February 2014

Coral reefs are threatened by disease. Using microfluidics and video microscopy to spy on the behavior of a coral pathogen, we discovered that it follows gradients of chemical cues leaking from the coral surface and responds more strongly to those coming from heat-stressed hosts.

 

HFSP Young Investigator Grant holder Ulrike Eggert and colleagues

Thursday 6th February 2014

Organisms use different types of biological building blocks to perform and regulate all of their functions. These building blocks, which include major biological molecules such as DNA, proteins and lipids, are assembled into cells and variations in their composition and localization are the basis for all biological processes. While biologists have a relatively good general understanding of how DNA and proteins work, we know very little about the functions of lipids.

 

HFSP Young Investigator Grant holders Monica Daley and Jonathan Hurst and colleagues

Monday 3rd February 2014

Robotic technologies have experienced a renaissance in recent years— yet the best humanoid robots remain far less capable of dynamic balance compared to humans and animals. We have discovered a simple control principle, inspired from running guinea fowl, which may help bipedal robots achieve the robust and agile athletic performance of these remarkable animals.

 

HFSP Long-Term Fellows Andrea Pauli and Eivind Valen and colleagues

Tuesday 28th January 2014

It has been assumed that most if not all signals that control early development are known. However, using genomics studies we identified several new candidate signals. We find that one of these - Toddler/Apela - is essential for embryogenesis by promoting the movement of cells during zebrafish gastrulation. Toddler/Apela signals through G-protein coupled receptors and might be the first in a series of previously uncharacterized developmental signals.

 

HFSP Long-Term Fellow Noam Kaplan and colleagues

Monday 27th January 2014

Although DNA sequencing technologies have advanced immensely in recent years, a typical published genome sequence may be fragmented in as many as 100,000 DNA fragments, due to the fact that full assembly of chromosomes is extremely difficult. We show how a simple genome-wide measurement of DNA 3D structural properties can be used to easily assemble and complete genome sequences in high-throughput for the first time.

 

HFSP Long-Term Fellow Schraga Schwartz and colleagues

Friday 24th January 2014

DNA, RNA and protein can all be modified following synthesis. These modifications have been relatively intensively studied in DNA and proteins, and have been found to dramatically impact the properties and the biological regulation of the molecules harboring them. However, far less is known about modifications on mRNA. N6-methyladenine (m6A) is a highly ubiquitous base modification occurring on mammalian mRNA. Discovered almost four decades ago, this modification is present within over 50% of mammalian...

 

HFSP Long-Term Fellow Eivind Valen and colleagues

Tuesday 14th January 2014

In 2010, the DNA molecules preserved in a 4,000 year-old tuft of hair found in Greenland’s permafrost delivered the first ancient human genome ever characterized. Now, three years later we have developed a new computational method to reconstruct nucleosome and methylation maps from this ancient genome based purely on genomic sequencing information. These maps can reveal which genes were expressed in the ancient individual, opening up an exciting new field in the study of ancient samples.

 

HFSP Career Development Award holder Jan Huisken and HFSP Program Grant holder Ingo Roeder and colleagues

Thursday 9th January 2014

High-resolution live imaging of embryonic development requires storage and processing of huge amounts of microscopy data, which precludes analysis of a large number of samples. We designed an imaging system that combines SPIM (Selective Plane Illumination Microscopy) with real-time image processing, dedicated to rapid imaging of entire zebrafish embryos. This approach extracts the desired information as images are being acquired and reduces the amount of data by a factor of 240, facilitating data...