Awardees' Articles

HFSP Long-Term Fellows Magda Bienko and Shalev Itzkovitz and colleagues

Thursday 24th January 2013

Visualizing specific DNA loci in their natural context – the cell’s nucleus – is fundamental to understanding how two meters of DNA can be packed in a space six orders of magnitude smaller. With this goal in mind, we have developed a simple but powerful quantitative method to rapidly and cost effectively engineer probes for visualizing virtually any locus in the human and mouse genome as well as entire chromosomes at high definition in single cells, using fluorescence in situ hybridization...


HFSP Cross-Disciplinary Fellow Askin Kocabas and colleagues

Thursday 17th January 2013

We combined optogenetics and new optical tools to control chemotactic behavior of Caenorhabditis elegans to understand the neural circuit that animals use to track chemo attractive gradients. We discovered that controlling the dynamics of activity in just one interneuron pair was sufficient to force the animal to locate, turn towards and track virtual light gradients.


HFSP Long-Term Fellow R’ada Massarwa and colleagues

Friday 4th January 2013

In-vivo imaging of the dynamic behaviors of tissues and cells during organ formation in mammals has been particularly challenging, due to their in utero development. This article describes a novel, prolonged and robust live imaging system for visualizing the formation of a variety of embryonic tissues in the mid-gestation mouse embryo.


HFSP Young Investigator Grant holders Attila Csikász-Nagy, Rafael Carazo-Salas and Masamitsu Sato and colleagues

Thursday 3rd January 2013

We developed a protein-protein interaction network analysis method to find the proteins which serve as links between cell cycle, cytokinesis and polarized cell growth regulation in fission yeast cells and experimentally verified the method on one of the predicted proteins.


HFSP Long-Term Fellow Zhiqiang Yan and colleagues

Friday 21st December 2012

Touch sensation is essential for behaviors ranging from environmental exploration to social interaction, but the underlying mechanisms are largely unknown. Here we found that class III dendritic arborization (da) neurons of Drosophila larvae are touch sensitive and contribute to gentle touch sensation. We further identify NOMPC (no mechanoreceptor potential C), as a pore-forming subunit of a mechanotransduction channel for gentle touch.


HFSP Young Investigator Grant holders Phillip Cassey, Tomas Grim and Mark Hauber and colleagues

Tuesday 18th December 2012

Birds produce some of the most colorful natural products: feathers and eggs. Surprisingly, the vast diversity of these colors is generated by just a handful of pigments and our HFSP Young Investigator team has worked on understanding how chemical simplicity in birds’ eggs generates its colorful appearance. We discovered that variation in the physical appearance of the eggshell color is not a reliable predictor of which pigments and in what relative concentration are incorporated into the eggshell...


HFSP Long-Term Fellow Daniel Koster and HFSP Program Grant holder Uri Alon and colleagues

Tuesday 18th December 2012

Bacteria are usually studied in well-mixed environments such as in shaken tubes or chemostats. However, bacteria often live on surfaces and migrate in space while they grow. The growth laws of such planar bacterial populations have been less studied. Here we employ a novel method for quantifying growth and gene expression in space and time and find that motile bacteria expand outward and continuously leave a portion of the population behind. The advancing bacteria grow and keep their density constant...


HFSP Long-Term Fellow Noam Stern-Ginossar and colleagues

Monday 17th December 2012

A closer look at the human cytomegalovirus genome uncovers many novel viral open reading frames.


HFSP Cross-Disciplinary Fellow Sabine Hauert and colleagues

Thursday 13th December 2012

Small interfering RNAs (siRNAs) are used to decrease the production of specific proteins in cells and promise new types of therapies to treat tumors. The challenge is to design drug-delivery tools capable of specifically transporting siRNAs to cancer cells. This paper systematically explores a variety of nanocomplex designs and identifies key criteria that allow them to enter cells and release siRNA cargo.


Review by HFSP Program Grant holders Henk Haagsman and Annelise Barron and colleagues

Monday 10th December 2012

Our paper highlights recent advances in the field of microfabricated encapsulating devices, emphasizing the development of emulsifying encapsulations, device design and current assays that are performed using encapsulating droplets on microfluidic chips.