Awardees' Articles

HFSP Long-Term Fellow Gabriel Rosenblum and colleagues

Tuesday 6th August 2013

Ribosomal synthesis of proteins proceeds with pauses that regulate the rhythm of protein synthesis. Mutations disrupting even relatively minor pauses can give rise to improperly formed proteins and human disease. Single molecule TIRF microscopy was used to monitor the expression of a full-length protein suggesting that tRNA selection plays an important general role in modulating the rates of protein synthesis, which potentially influences downstream co-translational processes such as folding and...

 

HFSP Long-Term Fellow Fernando Garcia-Moreno and colleagues

Friday 2nd August 2013

Most brain structures show evident similarities and agreed homologies. However, we have shown in the forebrain of avian and mammalian species a wide redistribution of gene expression and predicted homologies are not supported by transcriptomics.

 

HFSP Young Investigator Grant holders Michael Nevels, Felicia Goodrum and Eran Segal and colleagues

Tuesday 30th July 2013

Human cytomegalovirus (hCMV) is one of eight human herpesviruses and, by the age of 40, most of us will be infected with this virus. Although hCMV infections are usually harmless, the virus is the leading infectious cause of birth defects and a serious concern in immune-suppressed patients including transplant recipients.

 

HFSP Young Investigator Award holder Ido Golding and colleagues

Friday 26th July 2013

Gene expression is typically measured by averaging over millions of cells or by introducing reporters that perturb cellular function. A new method allows gene expression in individual, genetically unmodified bacterial cells to be quantified.

 

HFSP Career Development Award holder Hirokazu Tanaka and colleagues

Monday 22nd July 2013

The plant hormone auxin is directionally transported, accumulates locally, and triggers various developmental responses. Direction of auxin transport depends on tissue polarity, but it can change flexibly in response to environmental and developmental stimuli. Dynamic relocation of the PIN family of auxin transport proteins underlies this flexible regulation of auxin transport. We found that early endosomal proteins play important roles in PIN repolarization mediating multiple developmental pathways...

 

HFSP Career Development Award holder Marcelo Nollmann and colleagues

Monday 15th July 2013

How is DNA transported across membranes? We investigated the mechanism of DNA segregation by a bacterial DNA motor that uses the energy of ATP hydrolysis to power the movement of chromosomes across membranes during bacterial cell division.

 

HFSP Long-Term Fellow Manuel Irimia and colleagues

Tuesday 25th June 2013

Pluripotency is known to be regulated by a core set of transcription factors, chromatin modifiers and non-coding RNAs. Here, we show that the MBNL proteins negatively regulate a large program of alternative splicing with crucial roles in stem cell biology and somatic cell reprogramming, adding an extra regulatory layer to the control of pluripotency.

 

HFSP Career Development Award holder Alice Davy and colleagues

Friday 21st June 2013

Apical neural progenitors of the neocortex are polarized cells that are attached to an extracellular matrix both basally and apically. Adhesion must be finely regulated as strong attachment is necessary to ensure mechanical resistance of the tissue while detachment is required for neuronal differentiation. We discovered that apical adhesion of neural progenitors is controlled by neighboring cells and that cell-cell communication is important to maintain structural integrity of the developing cortex...

 

HFSP Long-Term Fellow Christof Gebhardt and colleagues

Tuesday 18th June 2013

Signals from individual fluorescent proteins in a cell nucleus are generally overwhelmed by out-of-focus background in common microscopy. We developed a microscopy method that restricts fluorescence excitation to a small horizontal nuclear section and thus enables fast single molecule imaging in living mammalian cells.

 

HFSP Long-Term Fellow Tim Lämmermann and colleagues

Friday 7th June 2013

Which molecules direct neutrophil swarm formation at sites of tissue damage and infection? We employed intravital microscopy of skin and lymph nodes to analyze neutrophil swarming upon sterile tissue injury and infection in mice, provide an initial molecular map of the factors that contribute to the coordinated neutrophil movement and aggregation, and show that “swarm”-like intercellular communication exists between neutrophils in the living tissue.