Awardees' Articles

HFSP Long-Term Fellow Bastien Boussau and colleagues

Tuesday 30th April 2013

Genomes are often analyzed in a historical, evolutionary framework. To establish this framework, we have developed a new method that reconstructs both gene trees and species trees with high accuracy.

 

HFSP Program Grant holders Maxime Dahan, Yohanns Bellaiche and Jacob Piehler and colleagues

Thursday 25th April 2013

Cellular functions like migration or division rely on the orchestration of different signaling networks both in time and in the intracellular space. While many tools have been developed over the years to observe these activities within the cell, only a few are able to create local and controlled biochemical activities inside cells. We have designed such a technique, based on magnetic nanoparticles, allowing the activation of signaling networks at the subcellular scale with an unprecedented spatiotemporal...

 

HFSP Long-Term Fellow Alphée Michelot and colleagues

Monday 15th April 2013

Cells often have partially redundant mechanisms to perform cellular functions, which can be an obstacle in deciphering molecular functions in a single mutant background. In this study, we were interested in determining how yeast cells control the elongation of actin filaments in endocytic actin networks and we successfully identified three partially overlapping mechanisms.

 

HFSP Long-Term Fellow Joseph Marsh and colleagues

Thursday 11th April 2013

The assembly of proteins into complexes underlies a wide variety of biological processes. By combining mass spectrometry experiments with large-scale analyses of protein structure, protein interaction and genome sequence data, we found that protein complexes have experienced evolutionary selection to assemble via well-defined, ordered pathways.

 

HFSP Long-Term Fellow Franz Hagn and colleagues

Thursday 4th April 2013

Structural studies of membrane proteins are still hampered by difficulties in finding appropriate membrane mimicking media that maintain protein structure and function. A novel membrane system, called phospholipid nanodiscs, consisting of a patch of lipids surrounded by two copies of a lipid-binding protein, recently became popular in the membrane protein field. In this system, membrane proteins can be investigated in a real detergent-free and native-like lipid environment. Smaller nanodiscs tailored...

 

HFSP Young Investigator Grant holders Kevin Dorfman, Pietro Cicuta, Bianca Sclavi and Marco Cosentino Lagomarsino and colleagues

Thursday 28th March 2013

Much like people, individuals in a population of bacteria respond differently to their environment. The experimental apparatus developed in this work allows HFSP-funded researchers to examine these responses under controlled chemical and nutrient conditions.

 

HFSP Long-Term Fellow Michael Meinecke and colleagues

Wednesday 27th March 2013

Clathrin-mediated endocytosis is a highly orchestrated process which involves over 40 proteins, many of which are transiently recruited to the plasma membrane. A bottom up approach to reconstitute cooperative membrane binding and membrane scission of proteins involved in the process was used to study this poorly understood problem.

 

Review by HFSP Long-Term Fellow Yun-Chi Tang and colleagues

Tuesday 26th March 2013

To ensure the species-specific karyotype is faithfully maintained thus upholding health and reproduction, numerous mechanisms have evolved to guarantee the integrity of genomic information. When errors happen, for instance from cell cycle checkpoint failures, the resulting DNA copy-number alterations can become detrimental, often identified as the cause of multiple diseases and developmental abnormalities in an organism. On the other hand, DNA copy-number alterations can contribute to enhancing...

 

HFSP Long-Term Fellow Albert Weixlbaumer and colleagues

Monday 18th March 2013

Access and retrieval of the genetic information stored in DNA is a fundamental process that requires tight regulation. Research by HFSP fellow Albert Weixlbaumer of The Rockefeller University has shed light on the molecular mechanism underlying a specific type of regulation, called transcriptional pausing, revealing more information about the first step of gene expression.

 

HFSP Young Investigator Grant holders Dimitrios Vavylonis and Naoki Watanabe and colleagues

Tuesday 12th March 2013

A mathematical analysis of two distinct microscopic experiments, which have been thought to contradict each other, provides a quantitative description of actin turnover and recycling mechanisms at the leading edge of crawling cells.