Awardees' Articles

Review by HFSP Long-Term Fellow Yun-Chi Tang and colleagues

Tuesday 26th March 2013

To ensure the species-specific karyotype is faithfully maintained thus upholding health and reproduction, numerous mechanisms have evolved to guarantee the integrity of genomic information. When errors happen, for instance from cell cycle checkpoint failures, the resulting DNA copy-number alterations can become detrimental, often identified as the cause of multiple diseases and developmental abnormalities in an organism. On the other hand, DNA copy-number alterations can contribute to enhancing...


HFSP Long-Term Fellow Albert Weixlbaumer and colleagues

Monday 18th March 2013

Access and retrieval of the genetic information stored in DNA is a fundamental process that requires tight regulation. Research by HFSP fellow Albert Weixlbaumer of The Rockefeller University has shed light on the molecular mechanism underlying a specific type of regulation, called transcriptional pausing, revealing more information about the first step of gene expression.


HFSP Young Investigator Grant holders Dimitrios Vavylonis and Naoki Watanabe and colleagues

Tuesday 12th March 2013

A mathematical analysis of two distinct microscopic experiments, which have been thought to contradict each other, provides a quantitative description of actin turnover and recycling mechanisms at the leading edge of crawling cells.


HFSP Career Development Award holder Tim Gollisch and colleagues

Thursday 7th March 2013

When visual contrast changes, neurons in the retina adapt by changing their sensitivity and temporal window of stimulus integration to better match the range of incoming signals. What happens, however, when contrast only changes in some parts of a scene, for example, when a high-contrast object appears in front of a low-contrast background? By analyzing the activity of retinal neurons under spatially local changes in contrast, we found that these neurons adapt in a global fashion, adjusting how...


HFSP Career Development Award holder Amir Amedi and colleagues

Monday 4th March 2013

A device which employs musical notes is helping blind individuals to “see” using sound. This non-invasive sensory-substitution device (SSD) was named the “EyeMusic” as it converts images into a combination of musical notes or “soundscapes” that propose alternate visional guidance for visually impaired or blind people.


HFSP Long-Term Fellow Wael Tadros and colleagues

Friday 1st March 2013

Understanding how the countless neurons of the central nervous system guide themselves through relatively large distances in order to find their specific synaptic targets is one of the most vital yet complex questions in neuroscience. We have used genetic and molecular manipulations at the single cell level to address how neurons in the fly connect the eye to the brain.


HFSP Long-Term Fellow Andre Brown and colleagues

Friday 15th February 2013

Short behaviours can be automatically identified from videos of crawling worms and used to discover genetic relationships between mutants. Automated methods for understanding changes in complex traits like behaviour are critical if we want to take full advantage of resources like the Million Mutation Project or large-scale gene knockout projects.


HFSP Long-Term Fellows Magda Bienko and Shalev Itzkovitz and colleagues

Thursday 24th January 2013

Visualizing specific DNA loci in their natural context – the cell’s nucleus – is fundamental to understanding how two meters of DNA can be packed in a space six orders of magnitude smaller. With this goal in mind, we have developed a simple but powerful quantitative method to rapidly and cost effectively engineer probes for visualizing virtually any locus in the human and mouse genome as well as entire chromosomes at high definition in single cells, using fluorescence in situ hybridization...


HFSP Cross-Disciplinary Fellow Askin Kocabas and colleagues

Thursday 17th January 2013

We combined optogenetics and new optical tools to control chemotactic behavior of Caenorhabditis elegans to understand the neural circuit that animals use to track chemo attractive gradients. We discovered that controlling the dynamics of activity in just one interneuron pair was sufficient to force the animal to locate, turn towards and track virtual light gradients.


HFSP Long-Term Fellow R’ada Massarwa and colleagues

Friday 4th January 2013

In-vivo imaging of the dynamic behaviors of tissues and cells during organ formation in mammals has been particularly challenging, due to their in utero development. This article describes a novel, prolonged and robust live imaging system for visualizing the formation of a variety of embryonic tissues in the mid-gestation mouse embryo.