Awardees' Articles

HFSP Young Investigator Grant holders Attila Csikász-Nagy, Rafael Carazo-Salas and Masamitsu Sato and colleagues

Thursday 3rd January 2013

We developed a protein-protein interaction network analysis method to find the proteins which serve as links between cell cycle, cytokinesis and polarized cell growth regulation in fission yeast cells and experimentally verified the method on one of the predicted proteins.

 

HFSP Long-Term Fellow Zhiqiang Yan and colleagues

Friday 21st December 2012

Touch sensation is essential for behaviors ranging from environmental exploration to social interaction, but the underlying mechanisms are largely unknown. Here we found that class III dendritic arborization (da) neurons of Drosophila larvae are touch sensitive and contribute to gentle touch sensation. We further identify NOMPC (no mechanoreceptor potential C), as a pore-forming subunit of a mechanotransduction channel for gentle touch.

 

HFSP Young Investigator Grant holders Phillip Cassey, Tomas Grim and Mark Hauber and colleagues

Tuesday 18th December 2012

Birds produce some of the most colorful natural products: feathers and eggs. Surprisingly, the vast diversity of these colors is generated by just a handful of pigments and our HFSP Young Investigator team has worked on understanding how chemical simplicity in birds’ eggs generates its colorful appearance. We discovered that variation in the physical appearance of the eggshell color is not a reliable predictor of which pigments and in what relative concentration are incorporated into the eggshell...

 

HFSP Long-Term Fellow Daniel Koster and HFSP Program Grant holder Uri Alon and colleagues

Tuesday 18th December 2012

Bacteria are usually studied in well-mixed environments such as in shaken tubes or chemostats. However, bacteria often live on surfaces and migrate in space while they grow. The growth laws of such planar bacterial populations have been less studied. Here we employ a novel method for quantifying growth and gene expression in space and time and find that motile bacteria expand outward and continuously leave a portion of the population behind. The advancing bacteria grow and keep their density constant...

 

HFSP Long-Term Fellow Noam Stern-Ginossar and colleagues

Monday 17th December 2012

A closer look at the human cytomegalovirus genome uncovers many novel viral open reading frames.

 

HFSP Cross-Disciplinary Fellow Sabine Hauert and colleagues

Thursday 13th December 2012

Small interfering RNAs (siRNAs) are used to decrease the production of specific proteins in cells and promise new types of therapies to treat tumors. The challenge is to design drug-delivery tools capable of specifically transporting siRNAs to cancer cells. This paper systematically explores a variety of nanocomplex designs and identifies key criteria that allow them to enter cells and release siRNA cargo.

 

Review by HFSP Program Grant holders Henk Haagsman and Annelise Barron and colleagues

Monday 10th December 2012

Our paper highlights recent advances in the field of microfabricated encapsulating devices, emphasizing the development of emulsifying encapsulations, device design and current assays that are performed using encapsulating droplets on microfluidic chips.

 

HFSP Program Grant holders Ignacio Tinoco and Harry Noller and colleagues

Friday 7th December 2012

The synthesis of a protein requires that the ribosome unwinds structures at the 5'-end of the messenger RNA to prevent inhibition of the translation initiation. Ribosomal protein S1 reversibly binds single-stranded RNA in steps of two or three nucleotides to uncover the site for ribosome binding and subsequent translation.

 

HFSP Young Investigator Grant holders Adam Engler and Guiseppe Battaglia and colleagues

Monday 3rd December 2012

Just like the bones that support your body, your cells have their own scaffolding to hold them up. This scaffolding, known as the extracellular matrix or ECM, not just props up cells but also provides attachment sites, or “sticky spots”, to which cells can bind, just as bones hold muscles in place.

 

HFSP Career Development Award holder Gregory Vert and colleagues

Thursday 29th November 2012

Our research has revealed distinct signaling pathways in the model plant Arabidopsis that control iron-deficiency responses and further highlights the complexity of the networks driving plant responses to low iron nutrition. Understanding how plants deal with iron deficiency is critical to human nutrition because vegetarian diets based on iron deprived crops may enforce anemia.