Awardees' Articles

HFSP Cross-Disciplinary Fellow Fernando Montealegre-Z and colleagues

Friday 16th November 2012

A newly identified hearing organ in a South American bush cricket, which possesses one of the smallest ears known, shows insect hearing is so sophisticated that it rivals our own. The study, published in Science, is the first to identify a hearing mechanism in an insect that is evolutionarily convergent to those of mammals.

 

HFSP Program Grant holders Derek Woolfson, Heiner Linker, Nancy Forde, Paul Curmi and colleagues

Tuesday 13th November 2012

There are many examples of peptides that self-assemble to form long, fibrous structures. Forming closed assemblies is more difficult. This HFSP-funded study shows that two α-helical peptides can be joined by a series of peptide linkers of different lengths to form a range of new peptide assemblies. The structure formed depends on the length of the linker employed, with short linkers favoring fibers and the longer linkers leading to closed nanostructures.

 

HFSP Long-Term Fellow Lars-Anders Carlson and colleagues

Monday 12th November 2012

Viruses are masters of using cells for their own purposes. We have synthetically recreated how HIV attracts so called ESCRT proteins - normally involved in cell division - to the sites where new virus particles are released from an infected cell.

 

HFSP Career Development Award holder Friedrich Förster and colleagues

Thursday 8th November 2012

In eukaryotic cells, co-translational protein translocation across the endoplasmic reticulum (ER) membrane requires an elaborate macromolecular machinery comprising the 80S ribosome and the translocon complex. Here, we used cryoelectron tomography and subtomogram averaging to provide a three-dimensional reconstruction of ER membrane associated 80S ribosomes and a description of their spatial organization in situ.

 

HFSP Career Development Award holder Jan Huisken and colleagues

Tuesday 30th October 2012

Photo damage and inappropriate mounting strategies limit the duration of in vivo imaging in conventional microscopy techniques. Combining light sheet microscopy with optimized mounting methods allows physiological imaging over days.

 

HFSP Long-Term Fellow Henning Tidow and Program Grant holder Poul Nissen and colleagues

Friday 19th October 2012

In eukaryotes, calmodulin-stimulated calcium pumps including plasma-membrane Ca2+-ATPases are key regulators in intracellular Ca2+ concentration. The precise mechanism of how these pumps are regulated remained elusive. Here, we identified a bimodular, calmodulin-mediated activation mechanism of plasma-membrane Ca2+-ATPases.

 

HFSP Program Grant holders Marie-France Carlier and Reinhard Lipowsky and HFSP Young Investigator Grant holder Guillaume Romet-Lemonne and colleagues

Friday 5th October 2012

The assembly-disassembly dynamics of cytoskeletal polymers such as actin filaments and microtubules support motile and morphogenetic processes in eukaryotes. Understanding the detailed molecular mechanisms by which these dynamic processes are controlled is a challenging task that requires combined biochemical and biophysical approaches. New technological developments in monitoring single actin filament dynamics with unprecedented accuracy and temporal resolution allows quantitative theoretical analysis...

 

HFSP Long-Term Fellow Michael Hiller and HFSP Young Investigator Grant holder Gill Bejerano and colleagues

Monday 1st October 2012

A comparative genomics approach predicts which genomic regions are linked to natural phenotypic differences between species, leveraging specificity resulting from independent phenotypic losses.

 

HFSP Career Development Award holder Fernando Martin-Belmonte and colleagues

Friday 28th September 2012

Cell confinement, by controlling cell spreading, defines the behavior of epithelial cells in the tissues. Low cell confinement limits peripheral actin contractility and promotes centrosome positioning and lumen initiation. This peripheral actin contractility depends on the RhoA–ROCK–myosin II pathway, which is downstream of master kinase Par-4/LKB1.

 

HFSP Cross-Disciplinary Fellow Gregory Sutton and colleagues

Thursday 27th September 2012

To jump as quickly as they do, insects use specialized spring-loaded structures to store and release large amounts of mechanical energy. To store this mechanical energy, the locust uses a structure composed of a layer of a soft protein called ‘resilin’ and a layer of hardened insect cuticle. This layering is similar to the construction of a composite bow.