Awardees' Articles

HFSP Career Development Award holder Oliver Daumke and colleagues

Monday 28th November 2011

Members of the dynamin superfamily are mechano-chemical GTPases which assemble at the surface of membranes and use the energy of GTP binding hydrolysis to apply a mechanical force to the underlying substrate. Here, X-ray structures of dynamin and the closely related antiviral MxA GTPase were elucidated which shed light on their molecular mechanism of action.

 

HFSP Program Grant Award holders Elizabeth Wright and Patrick Viollier and colleagues

Friday 25th November 2011

Bacteriophage (phage) use many methods to coordinate their adsorption and attachment to host bacteria. Some phages have tethers, which allow them to link to bacterial appendages, such as flagella and pili. In a recently published paper, we determined that the first interaction between two Caulobacter phages and the bacterial flagellum is through a filament located on the phage head.

 

HFSP Career Development Award holder Frank Schnorrer and colleagues

Monday 21st November 2011

Flying insects oscillate their wings at frequencies of up to 1000 times per second. These fast oscillations are powered by specialized fibrillar flight muscles, which develop under the control of the transcription factor Spalt major. Spalt major mutants are flightless and instead of fibrillar flight muscles form normal, slow moving body muscles only.

 

HFSP Program Grant Award holders Dimitrios Vavylonis and Naoki Watanabe and colleagues

Friday 18th November 2011

Advances in microscopic imaging continue to create unique demands for tracking multiple bright spots in time-lapse movies. We developed an open source, particle-tracking tool to obtain new results in single-molecule fluorescence microscopy.

 

HFSP Long-Term Fellow Fisun Hamaratoglu and colleagues

Thursday 17th November 2011

Scaling, matching of pattern to size, is a phenomenon that has enchanted generations of biologists. Here, we established the Drosophila wing imaginal disc, the precursor tissue to the adult wing, as a model to study scaling quantitatively during growth. We demonstrated that the morphogen Decapentaplegic (Dpp) and the feedback regulator Pentagone are key factors responsible for proportional tissue growth of the fruit fly wing.

 

HFSP Long-Term Fellow Sarel Fleishman and colleagues

Tuesday 15th November 2011

Interactions between proteins underlie all biological processes, including intracellular signalling and immune recognition and elimination of pathogens and cancer cells. The ability to design interactions between proteins could unlock the vast potential of subtle control over living processes and is a stringent test of our understanding of the most fundamental level of biological function.

 

HFSP Long-Term Fellow James Locke and colleagues

Monday 14th November 2011

We have observed a novel way of responding to stress. B. subtilis turns on a major stress response pathway in pulses, rather than by modulating steady state levels as previously thought. The frequency of these pulses increases as stress levels increase. Remarkably, this pulsating stress response requires a compact circuit consisting of only 3 genes and an input phosphatase.

 

Press release for HFSP Career Development Award holder Davide Corona and colleagues

Thursday 10th November 2011

Faced with sudden changes caused by environmental stimuli and stress, cells are called upon to make quick decisions. Thus, when there is a crisis – from the Greek krisis “choice” – cells must adapt their own normal genetic programming “reining in” the power of their engines, like ships suddenly needing to change course. Valerio Orlando at the Telethon Dulbecco Institute who works at the Santa Lucia Foundation in Rome, together with HFSP Career Development Award holder Davide Corona at...

 

HFSP Long-Term Fellow Geert van den Bogaart and colleagues

Monday 7th November 2011

Neurotransmitters are released following fusion of synaptic vesicles with the plasma membrane. This is mediated via so-called SNARE proteins such as syntaxin-1. Here we show that the enrichment of syntaxin-1 is mediated by interactions with the phospholipid phosphatidylinositol-4,5-bisphosphate (PIP2).

 

HFSP Cross-Disciplinary Fellow Patrick Heun and colleagues

Thursday 3rd November 2011

The primary constriction of a mitotic chromosome is called a centromere. It is readily visible under the microscope and was first described by Walter Flemming over 130 years ago. How the position of a centromere is chosen however, has been a long-standing question in the field of chromosome biology. We can now show that the histone protein CENH3 is necessary and sufficient for centromere formation and inheritance.