Awardees' Articles

HFSP Cross-Disciplinary Fellow Sven vanTeeffelen and HFSP Grant holders Ned Wingreen, Joshua Shaevitz and Zemer Gitai and colleagues

Thursday 3rd November 2011

Motor-induced dynamics of the cytoskeleton is well-studied in eukaryotic cells but had not been observed in bacteria. Our experiments reveal that an important component of the bacterial cytoskeleton is dragged around the periphery of rod-shaped cells of Escherichia coli as new cell wall is synthesized. Computational modeling indicates that these dynamics are important for bacterial morphogenesis.

 

HFSP Long-Term Fellow Joao Matos and colleagues

Monday 24th October 2011

How do cells ensure the timely separation of recombination intermediates and control the outcome of mitotic and meiotic recombination? A conserved regulatory network couples the actions of crossover-promoting nucleases to cell cycle progression, ensuring the efficient resolution of recombination intermediates, while biasing crossover outcome according to the requirements of meiosis and mitosis.

 

HFSP Young Investigator Grant holders Friedrich Simmel and Erik Winfree and colleagues

Monday 24th October 2011

We have used an artificial biochemical oscillator to drive the motion of a simple biomolecular nanodevice constructed from DNA. The way in which the coupling of the device to the oscillator affects the performance of the combined system sheds light on the general problem of modularity and “back-action” in complex biochemical systems.

 

HFSP Program Grant Award holders Nancy Forde, Heiner Linke and Paul Curmi and colleagues

Thursday 20th October 2011

Molecular motors are biological nanomachines involved in almost every aspect of cellular life. Inspired by these and to better understand and control motion at the nanoscale, an emerging area of research involves the synthesis of novel molecular motors from biomolecular building blocks. To guide the understanding of experimental results and provide predictions of future motor performance, computer simulations have provided insight into novel mechanisms exhibited by so-called molecular spiders, a...

 

HFSP Career Development Award holder Leonardo Salmena and colleagues

Tuesday 18th October 2011

We propose that newly discovered lines of communication between coding or noncoding RNAs form large-scale regulatory networks in cells through competition for microRNA. The existence of competing endogenous RNA (ceRNA) could offer answers to evolutionary questions, as it may partly explain the correlation of genome size and organism complexity.

 

HFSP Long-Term Fellow Bastien Boussau and colleagues

Thursday 13th October 2011

Vertebrate genomes contain a large portion of duplicated sequences, whose evolutionary origins are unclear. We found that duplications in the mitochondrial genomes of two vertebrate groups have probably fixed just by chance, and not through selection.

 

Press release for HFSP Long-Term Fellows Cagla Eroglu and Nicola Allen and colleagues

Tuesday 11th October 2011

Duke researchers have established the function of two proteins produced in the brain that can respectively stimulate and stop the formation and maturation of excitatory synapses, the nerve connections that are important for learning.

 

HFSP Long-Term Fellow Vera Bonardi and colleagues

Friday 7th October 2011

The major class of immune receptors in plants and animals is represented by NLRs (Nucleotide-binding domain leucine-rich repeat proteins). Bonardi and colleagues expand the textbook function for NLRs beyond recognition of specific pathogen effectors and suggest that a new activation mechanism can be used by these receptors. They report that a family of Arabidopsis NLR proteins function as ‘helpers’ for other conventional ‘pathogen sensor’ NLR-mediated responses. The ADR proteins perform...

 

HFSP Long-Term Fellow Michael Hothorn and colleagues

Monday 3rd October 2011

Plants, just like animals, use small molecule hormones to integrate the growth and development of their cells and tissues. The hormone receptor proteins that recognize these ligands are however very different in plants and animals. A new study now confirms that plants use signaling proteins normally found in bacteria to initiate certain hormone responses.

 

HFSP Long-Term Fellow Alexander Sigal and colleagues

Sunday 2nd October 2011

HIV can be suppressed but not cured with drugs. This is because a drug insensitive reservoir of infected cells persists and re-seeds infection when drug treatment is interrupted. We observed that a type of HIV spread which uses infected cells to find new cell targets for infection is insensitive to drugs, due to the high numbers of viruses per cell this mode of infection can deliver. This infection mode may cooperate in forming the reservoir of drug insensitive infection and is a possible barrier...