Awardees' Articles

HFSP Program Grant holder Douglas Altshuler and colleagues

Thursday 14th December 2017

Hummingbirds must maintain contact with flowers in order to collect nectar, which can be challenging when flowers or background vegetation move in the wind. How do hummingbirds control their flight to feed in a moving environment? In experimental scenarios where either the feeder or the visual background moves, hummingbirds fly to maintain body position relative to the background, instead of flying to track the position of the feeder.

 

HFSP Long-Term Fellow Kenzo Ivanovitch and colleagues

Tuesday 12th December 2017

Live 3D imaging analysis reveals the coordination that occurs between cardiac progenitor cells - cells that, similar to stem cells, can change into another specific type of cell - during heart development. We found that progenitor cells go through alternate phases of changing into cardiac muscle (differentiation) to help initiate early heart function, and assisting the heart tube to take on its shape (morphogenesis).

 

HFSP Cross-Disciplinary Fellow Philippe Roudot and colleagues

Tuesday 28th November 2017

In fluorescent imaging, the study of intracellular dynamics is often challenged by the fast and heterogeneous motions of particles that results in the imaging of unpredictable transitions in a dense field of particle displacement. We designed a new algorithm that interrogates multiple motion types in forward and backward temporal directions in a rigorous statistical framework and found that in addition to improving the tracking of heterogeneous dynamics, our method requires lower acquisition frequency...

 

HFSP Young Investigator Grant holders Diego Oyarzún and Fuzhong Zhang and colleagues

Tuesday 7th November 2017

Mathematical modeling and wet-lab engineering revealed how genetic tuning shapes biosensor function. Our findings enable precision engineering of gene circuits for basic science and microbial cell factories.

 

HFSP Long-Term Fellow Paola Tognini and colleagues

Wednesday 4th October 2017

In the last decades, evidence has shown that the circadian clock plays a major role in maintaining whole body metabolic homeostasis. Changes in the dietary regimen deeply affect the liver endogenous clock, however little is known about the effect of a food challenge on other peripheral clocks. Ketogenic diets are low carbohydrate diets that have become very popular to lose weight. This study demonstrates how a ketogenic diet strongly and specifically influences the endogenous clock and the circadian...

 

HFSP Program Grant holders Leif Schröder and Mikhail Shapiro and colleagues

Monday 25th September 2017

Using a refined ultra-sensitive magnetic resonance imaging approach, it was shown that the noble gas xenon not only lights up in car headlights but also yields switchable bright signals for MRI scans when being trapped in nano-sized protein containers. The findings offer new perspectives for following specific cellular functions in the context of entire living organisms, a challenge that requires novel reporters with no signal penetration limits and that should be minimally invasive to not hamper...

 

HFSP Long-Term Fellow Nir Fluman and colleagues

Tuesday 19th September 2017

Membrane proteins are inserted into the membrane co-translationally, one transmembrane helix after the other, as they emerge from the ribosome, yet it remains debatable whether helix insertion may remain dynamic at later stages. Contrary to earlier predictions, several studies have shown that certain helices can pop in or out of the membrane, or flip their orientation in the membrane, or even that whole proteins may perhaps change orientation, but it is not clear if such dynamic behaviors represent...

 

HFSP Career Development Award holder Emmanuel Levy and colleagues [with video]

Monday 18th September 2017

From symmetric complexes to micron-scale assemblies by single point mutations: we show how single point mutations frequently create new protein-protein interactions and can give rise to large assemblies in living cells. Unlike in amyloids, the proteins in these assemblies do not change shape or unfold in order to assemble.

 

HFSP Program Grant holder Marc Marti-Renom and colleagues

Friday 15th September 2017

In order to identify the structural determinant of the five different types (colors) of chromatin, we developed and applied a fully automatic computational pipeline to model the fly genome in 3D.

 

HFSP Long-Term Fellow Jinhong Luo and HFSP Program Grant holder Cynthia Moss

Monday 11th September 2017

Echolocating bats listen to their own vocalizations during sound production, instead of echo returns from nearby objects, for vocal control. These bats produce high frequency sounds and listen to echoes to find objects in their environment. Here, we precisely controlled the timing of acoustic jamming signals relative to bats' sonar call production to investigate the underlying auditory process used by bats for vocal production control. Our findings not only demonstrate that bats, like birds...