Awardees' Articles

HFSP Young Investigator Grant holders Tatiana Korotkova and Denis Burdakov and colleagues

Friday 10th March 2017

Food seeking is a complex behavior, crucial for survival. We identified a novel top-down pathway from medial prefrontal cortex to the lateral hypothalamus, which utilizes gamma synchronization to regulate food seeking by dynamic reorganization of functional cell groups in the hypothalamus.

 

HFSP Cross-Disciplinary Fellow Philip Bittihn and colleagues

Thursday 9th March 2017

Mutations in laboratory populations of simple organisms such as bacteria are of central interest in the context of experimental evolution and a major concern for bioengineers whose goal it is to equip them with evolutionarily stable added functionality. This study shows that the changes in population size as they are imposed by common experimental protocols can have a strong impact on the likeliness for mutations to spread through the population and makes quantitative predictions how the spectrum...

 

HFSP Long-Term Fellow Mariaceleste Aragona and colleagues

Tuesday 7th March 2017

One of the key questions in biology is to identify how tissues are repaired after trauma and understand how stem cells migrate, proliferate, and differentiate to repair tissue damage. We identified the cellular and molecular mechanisms that regulate wound healing in the skin.

 

HFSP Cross-Disciplinary Fellow Shalin Mehta and colleagues

Monday 6th March 2017

Directed functions of cells emerge from the nanoscale alignment of dynamic molecules. We have developed a new microscope and computational algorithms to analyze the alignment and orientation of dynamic biomolecules in live cells.

 

HFSP Program Grant holders Gohta Goshima and Marcel Janson and colleagues

Friday 3rd March 2017

How do cells define where they divide? The midbody in animals and the phragmoplast in plants are bipolar microtubule networks that coordinate cytokinesis. De Keijzer et al. demonstrate that the kinesin-4 dependent length of microtubule overlap zones in phragmoplasts confines the site of membrane deposition for septum formation.

 

HFSP Program Grant holders Joseph Corbo, Almut Kelber and Nicholas Roberts and colleagues

Thursday 2nd March 2017

Birds use four cone types to see the world in sparkling colours but this comes at a cost: colours fade away faster in dim light. Pooling signals from multiple cones helps them to still see colour, if only, with less detail.

 

HFSP Program Grant holders Andreas Plückthun and Gerhard Wagner and colleagues

Tuesday 28th February 2017

Membrane proteins play numerous biological roles, such as in signal transduction and viral entry, and are important drug targets. We engineered covalently circularized protein belts that can be used to stabilize patches of phospholipid bilayers, which provide a well-defined, extremely stable and near-native environment for the study of membrane proteins.

 

HFSP Long-Term Fellow Ella Preger-Ben Noon and colleagues

Monday 27th February 2017

Transcriptional systems exhibit extraordinary robustness. It is, therefore, unclear how such robust systems can evolve loss of expression through point mutations to cause evolutionary change. By deciphering the evolved regulatory changes in a robust enhancer of the shavenbaby gene, we discovered that gain of a repressor binding site can overcome transcriptional robustness encoded by multiple activator binding sites and contributes to morphological evolution.

 

HFSP Program Grant holders Belinda Chang and Massimo Olivucci and colleagues

Friday 24th February 2017

The reconstruction of the evolutionary history of light energy absorption and utilization in light-responsive proteins requires the integration of quantum chemistry and molecular evolution. We have started such integration by developing a computational protocol for the automatic construction of computer models of rhodopsins. The viability of this technology is demonstrated by reproducing the absorption maximum of distant rhodopsins and by studying the adaptation of a flock of fish to environments...

 

HFSP Program Grant holders Zachary Mainen and Alexandre Pouget and colleagues

Thursday 23rd February 2017

Nobody knows how the brain manages to identify individual scents within a mixture of odors. However, a new mathematical model may point the way to a solution.