Frontier science matters

Featuring topics related to frontier life science research that go beyond the research supported directly by HFSP. See also ...

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Greasing up ferroptotic cell death

By HFSP Program Grant alumnus Marcus Conrad

Ferroptosis is a novel, yet only partly understood, type of regulated necrotic cell death that may underlie some forms of degenerative diseases including neurodegeneration but that could also be harnessed to treat certain cancers. Oxidation of lipids in cellular membranes has been considered to be a central process in ferroptosis, yet the nature and source of lipid peroxidation has remained enigmatic. Two recent complementary studies from a 2014 HFSP Program Grant team, led by Marcus Conrad,...

How fish see infrared light: solving a 100-year old mystery in vision science

By HFSP Program Grant alumnus Joseph Corbo

In 1896, two German scientists, Köttgen and Abelsdorff, made a curious observation: when they measured the absorption properties of visual pigments (the molecules that mediate light sensation) extracted from the eyes of freshwater fish, they found them to be ‘red-shifted’ towards longer wavelengths than those of marine fish and land animals. The significance of this seemingly obscure discovery was not appreciated until nearly 40 years later, when George Wald took up the problem...