HFSP success stories

Featuring studies conducted by HFSP Awardees, both past and present. See also ...

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Happenchance and hedgehogs

By HFSP alumnus Philip Ingham

Earlier this year, the European Medicines Agency approved the use of a new anti-cancer drug, Erivedge, developed by Genentech in collaboration with the Cambridge (Mass) based biotech company Curis Inc, for the treatment of Basal Cell Carcinoma (BCC), the most common cancer amongst Caucasians. This decision followed similar approval for its clinical use in the USA by the FDA in 2012. The drug works by targeting a transmembrane protein called Smoothened that is a pivotal component of the...

OpenSPIM: an open access light sheet microscopy platform

OpenSPIM: an open access light sheet microscopy platform

Light sheet microscopy is an emerging technique that allows developmental and cell biologists to record entire living systems with minimal photo-damage over extended periods of time. The technology has thus far been applied to produce spectacular proof of principle recordings of model organism embryos which capture the developing specimen at cellular resolution throughout early development. True biological discoveries using this technology are, however, yet to be realized and will require that...