HFSP success stories

Featuring studies conducted by HFSP Awardees, both past and present. See also ...

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An HFSP fellowship that sowed the seeds for PROTAC drug development

By HFSP Short-Term Fellowship alumnus Alessio Ciulli

In 2009, Alessio Ciulli was awarded an HFSP Short-Term Fellowship* to support his 3-month research visit to Yale University to start a collaboration between his new lab and the lab of Professor Craig Crews at Yale. Crews, Ciulli and co-workers designed potent small molecules targeting the von Hippel-Lindau (VHL) E3 ligase, aiding development of much improved proteolysis targeting chimeric molecules (PROTACs). Today, only a few years after the beginning of this crucial collaboration, targeted...

A novel approach to handling membrane proteins in vitro: a daring HFSP grant that paid off

By HFSP Research Grant alumnus Jean-Luc Popot

In 2000, Jean-Luc Popot was awarded an HFSP Research Grant, together with his colleagues Edward A. Berry and Catherine Vénien-Bryan, to develop synthetic polymers called "amphipols", which they hoped would provide membrane biologists with new tools to handle membrane proteins in aqueous solutions. As briefly recounted below, this help proved absolutely decisive as the project was too novel, basic and risky to be fundable for a sufficient duration at the French or the European...