Optogenetic techniques have been applied to modulate genetically-targeted neurons and find their wide applications in neuroscience research field to understand the link between brain function and behavior. However, traditional optogenetic methods use optical fibers for light delivery, which could cause brain damages due to the invasive fiber implantation surgery. Recently, my host supervisor Dr. Huiliang Wang has co-developed a technology called Sono-opotogenetics that uses mechanoluminescent nanoparticles to convert focused ultrasound (FUS) to light for optogenetic stimulation. This technology does not require invasive surgery hence it is minimally-invasive to the animals. However, the FUS system used in this work requires head-fixation of the mice. Therefore, it could not be used for neuroscience studies in freely-behaving mice. Through the Human Frontier Science Program, I am aiming to develop a wireless, wearable ultrasound transducers for sono-optogenetic neuromodulation in freely-behaving mice. I will plan to fabricate flexible ultrasound transducers utilizing my micro-fabrication skills. I have gained over my PhD study in Korea and integrate with a wireless communication system. The proposed wearable focused ultrasound system together with sono-optogenetics technology, is expected to allow us to perform non-invasive sono-optogenetic stimulation in freely moving animals. For example, it could be a powerful genetically-targeted neuromodulation tools in cognitive or memory behavioral studies with freely moving animal in complex-structured mazes.