How do animals restore organ function after injury? This fundamental question is often approached from two distinct scientific perspectives. Neuroscientists typically study how the brain and behavior respond to damage, such as stroke or spinal cord injury, using mammalian models with limited regenerative capacity. Meanwhile, regenerative biologists focus on the amazing abilities of species that can regrow entire organs, investigating the cellular and molecular mechanisms underlying structural regeneration. However, these two fields rarely intersect, leaving a major gap in our understanding of how regenerated organs are functionally reintegrated into a fully developed nervous system. This project bridges neuroscience and regenerative biology by investigating functional recovery in a genetically accessible and highly regenerative invertebrate: the golden apple snail (Pomacea canaliculata). These snails can fully regenerate vertebrate-like eyes in adulthood, offering a unique opportunity to investigate how the nervous system adapts to restore vision and behavior after injury. We will combine classical and cutting-edge techniques in molecular biology, transcriptomics, genetic engineering, neural recordings and behavioral assays to obtain an integrated understanding of the changes occurring in the apple snail central nervous system after eye amputation and regeneration. By integrating these approaches, we aim to uncover the principles that allow biological systems to reestablish homeostasis and restore function after damage. This interdisciplinary research will not only advance our understanding of regeneration and neural plasticity but also inspire new strategies in regenerative medicine and bioengineering. By identifying the mechanisms that support functional recovery, our findings may inform future efforts to repair damaged tissues and restore lost functions in humans.