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Osmotic stress may trigger FUS pathology in dementia

The RNA-binding protein FUS, which localizes to the nucleus of normal neurons, forms cytoplasmic aggregates in a subset…

Contact directs myosin flow to orient cell division

During animal development, cell division orientations are arranged in diverse angles to shape tissue and organs, but…

The dark side versus the light side: how plants adapt to prolonged dark periods

A nuclear inactive reserve pool of the micro RNA biogenesis factor HYL1, in a phosphorylated state, is specifically…

Myosin1D regulates animal left-right asymmetry

The characterization of a unifying mechanism governing left-right asymmetry in different phyla has long remained…

A liquid phase of synapsin and lipid vesicles

Neuronal transmission relies on the sustained release of neurotransmitters from synaptic vesicles (SVs) upon…

SickKids

Toronto, Canada 2018

The 18th HFSP Awardees Meeting was held in Toronto, Canada from the 8 - 11 July, 2018

HFSPO policy on data privacy

Approach to classify, separate, and enrich objects in groups using ensemble sorting

We show a new method to sort objects in groups or using a set of registers, which are then resorted iteratively. The…

Optogenetic reconstitution of the cortical spindle-pulling machinery in human mitotic cells

During mitosis, dynamic plus ends of astral microtubules must be captured and pulled by cortical force-generating…

Live imaging of trans-homolog enhancer-promoter communication in Drosophila embryos

Transvection is a process where regulatory DNAs located on one homolog regulate the transcription unit on the other…

Global Biodata Coalition

Research resources are central to life science research and large databases are amongst the most important of these…

Evolving new genetic features has never been easier

Changes in gene regulatory networks often underlie evolutionary innovation, but it is unclear how evolutionarily…